Ignite Creation Date:
2024-05-06 @ 7:12 PM
Last Modification Date:
2024-10-26 @ 3:02 PM
Study NCT ID:
NCT05935280
Status:
COMPLETED
Last Update Posted:
2024-03-15
First Post:
2023-06-28
Brief Title:
Mechanism of Human Cold Pain Perception - Involvement of TRPA1 TRPM8 Nav17 and Nav18
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Human Cold Pain - a Single-group Randomized Placebo-controlled Adaptive Factorial Crossover Trial
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Animal studies suggest that the transient receptor potential ion channels TRPM8 and TRPA1 are cold sensors and that sodium channels Nav18 and Nav17 are essential for detecting pain induced by cold temperatures This study aims to validate these findings in humans
Detailed Description:
It is essential for human survival to be able to perceive potentially harmful cold The perception of slight cooling in animals depends on the ion channel TRPM8 but this may represent a largely separate mechanism from painful cold In mice TRPM8 and TRPA1 appear to be involved but also the sodium channels Nav17 and Nav18 through their temperature-dependent function These receptors might be redundant so that failure of individual receptors only leads to no or only a partial reduction in the detection of cold
Since results obtained in animals do not always translate to humans the investigators want to clarify whether TRPM8 TRPA1 Nav17 and Nav18 are involved in the perception of cold pain in humans
In order to induce cold pain experimentally an increasingly cooled solution down to 3C is injected into the skin and the inhibitors for the mentioned targets are added individually and in combination
Since results obtained in animals do not always translate to humans the investigators want to clarify whether TRPM8 TRPA1 Nav17 and Nav18 are involved in the perception of cold pain in humans
In order to induce cold pain experimentally an increasingly cooled solution down to 3C is injected into the skin and the inhibitors for the mentioned targets are added individually and in combination
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None