Ignite Creation Date:
2025-12-24 @ 7:13 PM
Ignite Modification Date:
2025-12-29 @ 10:50 AM
Study NCT ID:
NCT00585403
Status:
WITHDRAWN
Last Update Posted:
2021-01-25
First Post:
2007-12-26
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Exercise Changes to Peripheral Blood Mononuclear Cells in Children
Sponsor:
University of California, Irvine
Organization:
Study Overview
Official Title:
PBMC, Exercise and Children: Initial Mechanisms
Status:
WITHDRAWN
Status Verified Date:
2021-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Nonapplicable clinical trial
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this research is to determine how the peripheral immune system is altered by exercise and differences related to gender, pubertal status and health.
Detailed Description:
SPECIFIC AIMS:
1. To systematically measure for the first time in healthy children and adolescents the effects of brief bouts of exercise on:
1. Numbers of circulating PMBCs, their subsets and key intercellular adhesion molecules (ICAMs).
2. PBMC gene regulation of stress, inflammatory, and growth/repair mediators \[including: interleukin-4 (IL-4), IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma), growth hormone (GH), insulin-like growth factor-I (IGF-I), heat shock proteins (Hsp)\].
3. Circulating (serum) and intracellular PBMC levels of key mediators by flow cytometry and cell culture techniques.
4. Circulating endogenous triggers of PBMC mediator responses-soluble Hsp, IL-6, and F2-isoprostanes.
2. To determine how the acute PBMC responses are altered by gender, pubertal status, body composition (measured by whole-body and regional DEXA), and fitness (measured by progressive cycle ergometry and gas exchange).
3. To determine the relationship in healthy children and adolescents among acute PBMC responses to exercise, biochemical precursors of the metabolic syndrome (insulin, glucose, lipids), and the balance of the TH1/TH2 immune response.
1. To systematically measure for the first time in healthy children and adolescents the effects of brief bouts of exercise on:
1. Numbers of circulating PMBCs, their subsets and key intercellular adhesion molecules (ICAMs).
2. PBMC gene regulation of stress, inflammatory, and growth/repair mediators \[including: interleukin-4 (IL-4), IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma), growth hormone (GH), insulin-like growth factor-I (IGF-I), heat shock proteins (Hsp)\].
3. Circulating (serum) and intracellular PBMC levels of key mediators by flow cytometry and cell culture techniques.
4. Circulating endogenous triggers of PBMC mediator responses-soluble Hsp, IL-6, and F2-isoprostanes.
2. To determine how the acute PBMC responses are altered by gender, pubertal status, body composition (measured by whole-body and regional DEXA), and fitness (measured by progressive cycle ergometry and gas exchange).
3. To determine the relationship in healthy children and adolescents among acute PBMC responses to exercise, biochemical precursors of the metabolic syndrome (insulin, glucose, lipids), and the balance of the TH1/TH2 immune response.
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| HL-80947 | None | None | View |