Ignite Creation Date:
2024-05-06 @ 7:11 PM
Last Modification Date:
2024-10-26 @ 3:02 PM
Study NCT ID:
NCT05925322
Status:
RECRUITING
Last Update Posted:
2024-05-07
First Post:
2023-06-15
Brief Title:
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Sponsor:
Weill Medical College of Cornell University
Organization:
Weill Medical College of Cornell University
Study Overview
Official Title:
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality A Precision Imaging Trial
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators hypothesized that during the 9-week course of Engage Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality
Detailed Description:
Social disconnection peaks in middle and late life and leads to an increased risk of suicide persistent depression and poor response to psychosocial interventions There is a critical need to develop a mechanistic understanding of the link between social disconnection and suicidality identify biological targets and address targets with scalable interventions The investigators developed a novel psychotherapy Engage Connect aimed to improve functions of the Positive Valence System PVS that are impaired in suicidality through increased engagement in rewarding social activities This study will use state-of-the-art precision imaging methods and clinical measures to evaluate brain- and behavioral changes in the PVS during psychotherapy
Participants will
Be randomly assigned to 9-weekly sessions of either Engage Connect therapy or Symptom Review and Psychoeducation
Complete 4 research assessments
Complete 3 MRI scans
Participants will
Be randomly assigned to 9-weekly sessions of either Engage Connect therapy or Symptom Review and Psychoeducation
Complete 4 research assessments
Complete 3 MRI scans
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01MH133953 | NIH | None | httpsreporternihgovquickSearchR01MH133953 |