Ignite Creation Date:
2024-05-06 @ 7:11 PM
Last Modification Date:
2024-10-26 @ 3:02 PM
Study NCT ID:
NCT05927961
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-07-03
First Post:
2023-04-17
Brief Title:
Spatial Proteomics Profiles of Aldosterone-producing Adenoma and Unilateral Hyperplasia
Sponsor:
Third Military Medical University
Organization:
Third Military Medical University
Study Overview
Official Title:
Spatial Proteomics Profiles of Adrenal AdenomaHyperplasia Leading to Primary Aldosterone
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Primary aldosteronism PA is a common cause of secondary hypertension which is characterized by excessive aldosterone production by the adrenal gland Excessive aldosterone can significantly increase the risk of cardiovascular disease and stroke Patients with aldosterone-producing adenoma APA or unilateral hyperplasia UAH can be cured by unilateral adrenalectomy The adrenal cortex is the outer part of the adrenal gland and is subdivided into three layers- the zona glomerulosa the zona fasciculata and the zona reticularis And the outermost layer is the zona glomerulosa and its full of cells that make the hormone aldosterone Although it has been investigated that the main cause of APA or UAH is the mutations of different calcium ion channels including KCNJ5 CACNA1D CLCN2 et al it is still unknown whether there are any other changes of other proteins in different layers Therefore the investigators designed the study to characterize the proteomics profiles of adrenal adenomahyperplasia leading to primary aldosterone and identify biomarkers for early identification of PA by using spatial proteomics The samples from adrenal adenoma or hyperplasia will be collected and analyzed by spatial proteomics in Hangzhou Jingjie Biotechnology Co Ltd The differentially expressed proteins in different layers will be screened out between APA and UAH APA and its adjacent normal tissues and UAH and its adjacent normal tissues respectively And KEGG analysis will be conducted to determine enriched pathway in these differentially expressed protein respectively
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None