Ignite Creation Date:
2024-05-06 @ 7:10 PM
Last Modification Date:
2024-10-26 @ 3:01 PM
Study NCT ID:
NCT05910138
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-06-22
First Post:
2023-06-11
Brief Title:
Evaluation of Serum Levels of Interlukin-15 and Interlukin-21 in Patients With Alopecia Areata
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Evaluation of Serum Levels of Interlukin-15 and Interlukin-21 in Patients With Alopecia Areata
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Alopecia areata AA is a type of non-cicatricial alopecia The most common presentation of AA is localized patches of hair loss on the scalp The extensive forms of AA presented as diffuse hair loss of the scalp alopecia totalis and diffuse hair loss through the entire body including the eyelashes and eyebrows alopecia universalis
AA affects approximately 2 of the general population AA occurs at any age The peak of incidence is higher in the second and third decades of life
AA may be associated with several autoimmune diseases including thyroid diseases lupus erythematosus vitiligo psoriasis rheumatoid arthritis and inflammatory bowel disease The frequency of the disease varies between geographically separate populations These diseases associations suggest a relationship between AA and autoimmunity
Human hair has an important cosmetic and communicational role We may find significant psychological distress in persons with partial and complete hair loss AA is associated with psychiatric morbidity especially anxiety and depression
The pathogenesis of AA involves a complex interaction between genetic environmental and immune factors The histopathology of the disease differs according to the stage of the disease In the acute stage of AA there is a dense accumulation of lymphocytes CD4 CD8 around hair bulbs so called swarm of bees In chronic stage the inflammation may or may not resolve but there is increase in number of catagen and or telogen hair and pigmentary incontinence In the recovery stage there is minimal inflammation and increase in anagen hair
T-helper17 cells are unique subset of T-helper cells which produce many interleukins IL eg IL-17A IL-17F IL-21 IL-22 IL-6 and tumor necrosis factor TNF The maturation of Th-17 needs the stimulation of naïve T cells by both TGF and IL-21 IL-21 is a cytokine that is produced mostly by activated CD4 T cells It controls the differentiation and activity of T cells B cells and NK cells IL-21 could be a promising marker in the diagnosis of AA and also can be used as a marker of its activity
IL-15 is a pleotropic cytokine that has multiple effects on different body cell types It affects the function of cells of both innate and adaptive immune system IL-15 is well known to promote lymphocytic development and suggested to play a role in some autoimmune diseases eg multiple sclerosis rheumatoid arthritis ulcerative colitis and celiac disease IL-15 inhibits the well-known self-tolerance that mediated by activation - induced cell death promotes maintenance of CD8 memory T cells with induction of some cytokines which involved in autoimmune process eg TNF- and IL-1B IL-15 is positively correlated with the number and the extent of AA so it could be a possible marker of AA severity
AA affects approximately 2 of the general population AA occurs at any age The peak of incidence is higher in the second and third decades of life
AA may be associated with several autoimmune diseases including thyroid diseases lupus erythematosus vitiligo psoriasis rheumatoid arthritis and inflammatory bowel disease The frequency of the disease varies between geographically separate populations These diseases associations suggest a relationship between AA and autoimmunity
Human hair has an important cosmetic and communicational role We may find significant psychological distress in persons with partial and complete hair loss AA is associated with psychiatric morbidity especially anxiety and depression
The pathogenesis of AA involves a complex interaction between genetic environmental and immune factors The histopathology of the disease differs according to the stage of the disease In the acute stage of AA there is a dense accumulation of lymphocytes CD4 CD8 around hair bulbs so called swarm of bees In chronic stage the inflammation may or may not resolve but there is increase in number of catagen and or telogen hair and pigmentary incontinence In the recovery stage there is minimal inflammation and increase in anagen hair
T-helper17 cells are unique subset of T-helper cells which produce many interleukins IL eg IL-17A IL-17F IL-21 IL-22 IL-6 and tumor necrosis factor TNF The maturation of Th-17 needs the stimulation of naïve T cells by both TGF and IL-21 IL-21 is a cytokine that is produced mostly by activated CD4 T cells It controls the differentiation and activity of T cells B cells and NK cells IL-21 could be a promising marker in the diagnosis of AA and also can be used as a marker of its activity
IL-15 is a pleotropic cytokine that has multiple effects on different body cell types It affects the function of cells of both innate and adaptive immune system IL-15 is well known to promote lymphocytic development and suggested to play a role in some autoimmune diseases eg multiple sclerosis rheumatoid arthritis ulcerative colitis and celiac disease IL-15 inhibits the well-known self-tolerance that mediated by activation - induced cell death promotes maintenance of CD8 memory T cells with induction of some cytokines which involved in autoimmune process eg TNF- and IL-1B IL-15 is positively correlated with the number and the extent of AA so it could be a possible marker of AA severity
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None