Ignite Creation Date:
2024-05-06 @ 7:10 PM
Last Modification Date:
2024-10-26 @ 3:01 PM
Study NCT ID:
NCT05919667
Status:
COMPLETED
Last Update Posted:
2023-06-26
First Post:
2022-02-28
Brief Title:
Dairy and Non-Dairy Alternatives Comparative on Metabolic Outcomes
Sponsor:
University of Toronto
Organization:
University of Toronto
Study Overview
Official Title:
The Effects of Dairy and Non-Dairy Alternatives on Glycemic and Appetite Regulation in Healthy Young Adults
Status:
COMPLETED
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to compare the acute effects of a single serving of dairy and non-dairy alternatives on post-treatment and post-meal glycemia appetite plasma amino acid concentrations and gastrointestinal hormones levels
Detailed Description:
In the past forty years the prevalence of obesity in adults has doubled with nearly two thirds of Canadian adults currently overweight or obese The global epidemic of obesity also makes certain individuals more vulnerable to common co-morbidities of obesity such as type-2-diabetes To combat these rising numbers Health Canada released a new Canadian Food Guide CFG in 2019 One particular alteration to the new CFG includes dietary guidelines encouraging for an increased consumption of plant-based foods as protein rich sources shifting away from the promotion of animal-based food products such as dairy However many of the available plant-based substitutes in the market are highly processed with high amounts of sugar fat sodium and additives compared to animal-based products While literature has shown for plant-based foods to confer numerous health benefits these are often plant-based foods that have been unprocessed except for cooking As the demand for plant-based products continues to grow annually it is important to assess and compare various obesity and T2D related metabolic outcomes such as glycemic regulation and appetite control to better understand the physiological functionality of these products and what role they may or may not play in mitigating the obesity and T2D global epidemics There is a growing body of evidence from clinical and meta-analysis trials that show dairy products reduce satiety and provide better glycemic control highlighting their potential to help reduce risk factors associated with obesity and T2D However literature has mainly focused on nutrient profile or isolated protein comparatives between animal and plant-based sources Instead this study will be looking at comparing dairy products and their plant-based counterparts with respect to their food matrix as a whole to understand what responses these products produce in the form consumers are naturally eating them by This study will focus on assessing the metabolic outcomes related to satiety and glycemic regulation Satiety is an important physiological function related to food intake and thus provides a measure to assess reduced obesity risk Additionally postprandial glycemic control is an important physiological function that is not only related to the development of type-2 diabetes but also satiety
A total of 16 participants 8 males and 8 females will participate in this study at the University of Toronto
The study will include a total of 5 sessions over the span of 5 weeks Prior to the visit participants will be fasted for 12 hours excluding water for up to 1 hour before the study visit During each session participants will consume a dairy product or a non-dairy plant-based product while subjective appetite blood glucose insulin C-peptide and gut hormones ghrelin GLP-1 GLP-2 and GIP are obtained post-treatment at 20 min and post a secondary fixed meal of pasta within 15-30 min intervals over a 2 hour timespan Plasma amino acid concentrations will also be measured within the same timeline outlined above
A total of 16 participants 8 males and 8 females will participate in this study at the University of Toronto
The study will include a total of 5 sessions over the span of 5 weeks Prior to the visit participants will be fasted for 12 hours excluding water for up to 1 hour before the study visit During each session participants will consume a dairy product or a non-dairy plant-based product while subjective appetite blood glucose insulin C-peptide and gut hormones ghrelin GLP-1 GLP-2 and GIP are obtained post-treatment at 20 min and post a secondary fixed meal of pasta within 15-30 min intervals over a 2 hour timespan Plasma amino acid concentrations will also be measured within the same timeline outlined above
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None