Ignite Creation Date:
2024-05-06 @ 7:09 PM
Last Modification Date:
2024-10-26 @ 3:01 PM
Study NCT ID:
NCT05915676
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-06-23
First Post:
2023-06-14
Brief Title:
Role of LILRA3 in Ankylosing Spondylitis and Axial Psoriatic Patients
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Frequency Assessment of Leukocyte Immunoglobulin-like Receptors A3 In Ankylosing Spondylitis And Axial Psoriatic Arthritis Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 To evaluate the frequency of LILRA3 in Ankylosing spondylitis and Axial psoriatic arthritis patients
2 To investigate the association of LILRA3 with Ankylosing spondylitis and Axial psoriatic arthritis disease activity and severity
2 To investigate the association of LILRA3 with Ankylosing spondylitis and Axial psoriatic arthritis disease activity and severity
Detailed Description:
Axial spondyloarthritis axSpA is a complex inflammatory condition that affects the axial skeleton including the sacroiliac joints and the spine 1 It also affects peripheral joints and can be associated with extra-musculoskeletal manifestations including uveitis psoriasis and inflammatory bowel disease 1
Axial spondyloarthritis include ankylosing spondylitis AS certain forms of psoriatic arthritis PsA reactive arthritis with axial involvement and arthritis associated with inflammatory bowel disease 2
The diagnosis of axSpA remains very challenging with years of delays attributed to several different factors There is also a strong need to identify new serological biomarkers that can aid clinicians for diagnosis of axSpA
Leucocyte immunoglobulin-like receptor A3 LILRA3 belongs to a family of leucocyte receptors produced as a soluble molecule by monocytes and macrophages 3 The function of LILRA3 remains obscure but LILRA3 could bind to HLA class I molecules HLA-G and HLA- C 4 and may act as an antagonist on other LILRs or a soluble ligand to other receptors5 Growing evidence shows that LILRA3 is associated with many autoimmune disorders6 7 The functional LILRA3 is a susceptibility factor for AS and axial psoriatic arthritis axPsA has not been investigated
Axial spondyloarthritis include ankylosing spondylitis AS certain forms of psoriatic arthritis PsA reactive arthritis with axial involvement and arthritis associated with inflammatory bowel disease 2
The diagnosis of axSpA remains very challenging with years of delays attributed to several different factors There is also a strong need to identify new serological biomarkers that can aid clinicians for diagnosis of axSpA
Leucocyte immunoglobulin-like receptor A3 LILRA3 belongs to a family of leucocyte receptors produced as a soluble molecule by monocytes and macrophages 3 The function of LILRA3 remains obscure but LILRA3 could bind to HLA class I molecules HLA-G and HLA- C 4 and may act as an antagonist on other LILRs or a soluble ligand to other receptors5 Growing evidence shows that LILRA3 is associated with many autoimmune disorders6 7 The functional LILRA3 is a susceptibility factor for AS and axial psoriatic arthritis axPsA has not been investigated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None