Ignite Creation Date:
2024-05-06 @ 7:07 PM
Last Modification Date:
2024-10-26 @ 3:01 PM
Study NCT ID:
NCT05907733
Status:
RECRUITING
Last Update Posted:
2023-06-18
First Post:
2023-06-08
Brief Title:
Brain-derived Neurotrophic Factor BDNF Single Nucleotide Gene Polymorphism and Nerve Growth Factor as Risk Factors That Increase Severity of Allergic Rhinitis
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Brain-derived Neurotrophic Factor BDNF Single Nucleotide Gene Polymorphism and Nerve Growth Factor as Risk Factors That Increase Severity of Allergic Rhinitis
Status:
RECRUITING
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Allergic diseases such as asthma allergic rhinitis AR and atopic dermatitis affect more than 25 of the world population and are the leading cause of illness in children The complex interplay between genetic environmental and immunological risk factors results in the manifestation of allergic diseases The pathological presentation of allergic disease involves the activation of both the innate and adaptive immune systems resulting in a multifaceted response in specific target tissues such as the airways This response results in the recruitment of inflammatory cells to target tissues and the production of specific IgE antibodies cytokines and other inflammatory mediators 11 12 It is well established that allergic inflammation triggers neuronal dysfunction which activates specific inflammatory mechanisms potentially leading to structural changes in the diseased tissue Neurotrophins are a family of structurally related proteins initially discovered to be involved in regulating neuronal development and now known to govern both peripheral and central nerve growth
BDNF is a secretory protein belonging to the neurotrophin family and is involved in a range of neural processes during human development 19 20 In the early stages of development BDNF is essential for neurogenesis survival and maturation of neuronal pathways In the adult alongside neurotransmitters hormones and other neurotrophins BDNF maintains synaptic plasticity dendritic growth and the consolidation of long-term memory The biological effect of BDNF is mediated via its binding to the trkB receptor The activation of these receptors on eosinophils may be important in regulating the inflammatory cascade leading to allergic disease 15 24 Neurotrophin mediated activation of bronchial eosinophils might therefore play a role in the regulation of eosinophilic inflammation in allergic asthma
The BDNF gene is located on chromosome 11p13 and is alternatively spliced resulting in several different transcripts 26 Genetic polymorphisms in BDNF have been associated with allergic phenotypes such atopic dermatitis 27 and asthma 28 29 30 31 in different populations The functional polymorphism rs6265 Val66Met has been shown to regulate intracellular trafficking and affect the secretion of BDNF 32 Nerve growth factor NGF a neurotrophin that is expressed in the glandular nasal epithelium and peripheral nerves in the nasal mucosa has been shown to induce biochemical and structural changes in nerves that can lead to hyper-responsiveness 33 34 35 The biological effects of neurotrophins are mediated by binding either to the high-affinity tyrosine kinase trk receptors or to the low-affinity receptors known as pan-neurotrophin receptor p-75
BDNF is a secretory protein belonging to the neurotrophin family and is involved in a range of neural processes during human development 19 20 In the early stages of development BDNF is essential for neurogenesis survival and maturation of neuronal pathways In the adult alongside neurotransmitters hormones and other neurotrophins BDNF maintains synaptic plasticity dendritic growth and the consolidation of long-term memory The biological effect of BDNF is mediated via its binding to the trkB receptor The activation of these receptors on eosinophils may be important in regulating the inflammatory cascade leading to allergic disease 15 24 Neurotrophin mediated activation of bronchial eosinophils might therefore play a role in the regulation of eosinophilic inflammation in allergic asthma
The BDNF gene is located on chromosome 11p13 and is alternatively spliced resulting in several different transcripts 26 Genetic polymorphisms in BDNF have been associated with allergic phenotypes such atopic dermatitis 27 and asthma 28 29 30 31 in different populations The functional polymorphism rs6265 Val66Met has been shown to regulate intracellular trafficking and affect the secretion of BDNF 32 Nerve growth factor NGF a neurotrophin that is expressed in the glandular nasal epithelium and peripheral nerves in the nasal mucosa has been shown to induce biochemical and structural changes in nerves that can lead to hyper-responsiveness 33 34 35 The biological effects of neurotrophins are mediated by binding either to the high-affinity tyrosine kinase trk receptors or to the low-affinity receptors known as pan-neurotrophin receptor p-75
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None