Ignite Creation Date:
2024-05-06 @ 7:07 PM
Last Modification Date:
2024-10-26 @ 3:01 PM
Study NCT ID:
NCT05903521
Status:
RECRUITING
Last Update Posted:
2023-09-15
First Post:
2023-06-06
Brief Title:
BAriatric Surgery Induced Chromosomal Change
Sponsor:
The Cleveland Clinic
Organization:
The Cleveland Clinic
Study Overview
Official Title:
Long-term Impact of Surgically Induced Rapid Weight Loss on Telomere Length and Its Potential Implications in the Genesis and Prevention of Neoplastic Disease Processes in Subjects With Severe Obesity
Status:
RECRUITING
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BASICC
Brief Summary:
The purpose of this study is to better understand the impact of weight-loss surgery on telomere length Telomeres are a key marker of biological aging of cells Telomere shortening is a natural process of aging Several pathologies and lifestyles are associated with premature telomere shortening such as obesity diabetes mellitus or sedentary lifestyle New evidence supports that telomere shortening can be partially reversed by lifestyle changes such as healthy diet reduced stress or increased physical activity
Detailed Description:
This study aims to evaluate the impact of metabolic and bariatric surgery on telomere length as well as the role of type 2 diabetes resolution and oxidative stress improvement on telomere lengthening
The investigators hypothesize that metabolic and bariatric surgery is associated with the lengthening of telomeres as a possible underlying mechanism of cancer risk reduction
It is a prospective single-center study including patients with obesity class II or more Body Mass Index 35kgm2 and patients having had metabolic and bariatric surgery more than 12 months ago
The investigators hypothesize that metabolic and bariatric surgery is associated with the lengthening of telomeres as a possible underlying mechanism of cancer risk reduction
It is a prospective single-center study including patients with obesity class II or more Body Mass Index 35kgm2 and patients having had metabolic and bariatric surgery more than 12 months ago
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None