Ignite Creation Date:
2024-05-06 @ 7:07 PM
Last Modification Date:
2024-10-26 @ 3:01 PM
Study NCT ID:
NCT05905289
Status:
COMPLETED
Last Update Posted:
2024-02-09
First Post:
2023-06-07
Brief Title:
Survival and Reproductive Outcomes of Malignant Ovarian Germ Cell Tumors
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Survival and Reproductive Outcomes After Fertility-sparing Surgery and Adjuvant Chemotherapy in Malignant Ovarian Germ Cell Tumors
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Malignant ovarian germ cell tumor patients conducted fertility-sparing surgery and adjuvant chemotherapy in Kasr El-Aini Hospital - Faculty of Medicine - Cairo University from January 2012 to December 2016 will be retrospectively investigated
Detailed Description:
MOGCT patients conducted fertility-sparing surgery and adjuvant chemotherapy with complete follow up data younger than 35 years old at first treatment in Kasr El-Aini Hospital - Faculty of Medicine - Cairo University Department of Obstetrics Gynecology and Center of Clinical Oncology and Nuclear Medicine from January 2012 to December 2016 will be retrospectively investigated
Diagnosis of MOGCT was revealed by pelvic mass abdominal pain and elevated tumor markers like α-fetoprotein AFP human choionic gonadotophin HCG and lactate dehydrogenase LDH and confirmed by surgical procedure and pathological diagnosis Pathological diagnosis was confirmed according to the 2014 World Health Organization classification of tumors of female reproductive organs Tumors were staged according to American Joint Committee of Cancer AJCC TNM and FIGO staging system for Ovarian and Primary Peritoneal Cancer
Fertility sparing surgery preserves uterus and the contralateral ovary with or without comprehensive staging omentectomy and lymphadenectomy by open laparotomy Adjuvant chemotherapy was scheduled based on histopathology grade and stage All patients received chemotherapy but with different schemes and courses The data including subjects demographics clinical and pathological characteristics treatment received survival outcome and reproductive outcomes including pregnancy rate natural conception and live birth rate will be investigated Follow-up data until January 31 2022 will be collected from hospital records and telephone interview
Diagnosis of MOGCT was revealed by pelvic mass abdominal pain and elevated tumor markers like α-fetoprotein AFP human choionic gonadotophin HCG and lactate dehydrogenase LDH and confirmed by surgical procedure and pathological diagnosis Pathological diagnosis was confirmed according to the 2014 World Health Organization classification of tumors of female reproductive organs Tumors were staged according to American Joint Committee of Cancer AJCC TNM and FIGO staging system for Ovarian and Primary Peritoneal Cancer
Fertility sparing surgery preserves uterus and the contralateral ovary with or without comprehensive staging omentectomy and lymphadenectomy by open laparotomy Adjuvant chemotherapy was scheduled based on histopathology grade and stage All patients received chemotherapy but with different schemes and courses The data including subjects demographics clinical and pathological characteristics treatment received survival outcome and reproductive outcomes including pregnancy rate natural conception and live birth rate will be investigated Follow-up data until January 31 2022 will be collected from hospital records and telephone interview
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None