Ignite Creation Date:
2024-05-06 @ 7:07 PM
Last Modification Date:
2024-10-26 @ 3:00 PM
Study NCT ID:
NCT05892055
Status:
WITHDRAWN
Last Update Posted:
2023-06-07
First Post:
2019-02-19
Brief Title:
Brain Mechanisms of Attention and Pain in Youth With FAPD
Sponsor:
Michigan State University
Organization:
Michigan State University
Study Overview
Official Title:
Brain Mechanisms of Attention and Pain in Youth With Functional Abdominal Pain Disorders
Status:
WITHDRAWN
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
No participants were enrolled for the active phase of this study with neuroimaging but n6 n3 with FAPD and n3 Healthy completed the pilot testing protocol outside of the scanner between 2282019 and 3282019 No neuroimaging took place
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objectives of this study are to identify neural mechanisms of increased pain in pediatric FAPD and examine mechanisms of disrupted attention in the presence of induced pain The overarching goal is to determine whether youth with FAPD process pain differently than healthy youth and to identify the brain areas involved
Detailed Description:
The goal of the current project is to enhance understanding of the neural mechanisms associated with the pain experience in youth with functional abdominal pain disorders FAPD which is the most common and debilitating presentation of FAPD This study will examine the neural mechanisms associated with pain induction and diminished attentional regulation during pain in FAPD Findings from pilot studies indicate that increased anxiety in FAPD is associated with higher pain-related impairment and that anxiety may adversely impact response to a cognitive behavioral intervention for pain While pain outcomes improve when anxiety is also addressed in treatment for FAPD a sizable portion fail to respond to currently available interventions Further the PI found that induced pain in FAPD is associated with changes in regional brain activity and functional connectivity between brain regions that are implicated in chronic pain It is crucial to better understand the neural mechanisms which may place youth with FAPD at risk for poorer outcomes in order to ultimately develop more effective treatments In this study neural mechanisms of response to a pain symptom provocation task in youth with FAPD will be compared to healthy controls The impact of anxiety levels will also be explored This study will also examine neural mechanisms associated with disrupted attentional regulation during pain induction in youth with FAPD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None