Ignite Creation Date:
2024-05-06 @ 7:07 PM
Last Modification Date:
2024-10-26 @ 3:00 PM
Study NCT ID:
NCT05899439
Status:
RECRUITING
Last Update Posted:
2024-02-28
First Post:
2023-05-22
Brief Title:
Immune Function and the Progression to T1D
Sponsor:
University of Florida
Organization:
University of Florida
Study Overview
Official Title:
Immune Function and the Progression to Type 1 Diabetes
Status:
RECRUITING
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To elucidate the mechanisms by which type 1 diabetes-associated genes IFIH1 TYK2 IKZF4 as well as total genetic risk impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells defective regulatoryeffector mechanisms in T cells inflammatory antigen presenting cells and abnormal immune function in T cells and B cells
Detailed Description:
Newly proposed studies will identify the inflammatory cues that draw immune cells into islets for disease initiation Project 1 probe the motility of immune cells through inflamed vasculature to the target organ and antigen priming sites within secondary lymphatics Project 2 and characterize the T1D-associated adaptive immune signatures in blood and immune tissues Project 3
The overall hypothesis of the renewed P01 states 1 the impact of T1D-risk variants will vary by tissue cell subset and activation state and 2 risk variants cellular stress and defects in immunologic pathways are key to engender the autoimmune destruction of pancreatic B-cells that results in T1D
The overall hypothesis of the renewed P01 states 1 the impact of T1D-risk variants will vary by tissue cell subset and activation state and 2 risk variants cellular stress and defects in immunologic pathways are key to engender the autoimmune destruction of pancreatic B-cells that results in T1D
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P01AI042288 | NIH | University of Florida | httpsreporternihgovquickSearchP01AI042288 |
| PRO00043521 | OTHER | None | None |