Ignite Creation Date:
2024-05-06 @ 7:06 PM
Last Modification Date:
2024-10-26 @ 3:00 PM
Study NCT ID:
NCT05891678
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2023-11-28
First Post:
2023-03-03
Brief Title:
The Value of Doppler Study of Central Retinal Artery in Diagnosis of Increased ICP
Sponsor:
Inas Ahmed Sayed Ammar
Organization:
Cairo University
Study Overview
Official Title:
The Value of Doppler Study of Central Retinal Artery in Diagnosis of Increased ICP
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to evaluate the diagnostic value of central retinal artery Doppler study in case of increased intracranial pressure
Detailed Description:
In neurocritical care the detection of raised intracranial pressure ICP remains crucial as it is associated with poor outcome Invasive ventricular devices are the gold standard for continuous and reliable measurement of ICP however their placement could be challenging due to blood coagulation disorder or lack of surgical availability Moreover malfunction or obstruction of ventricular catheters has been reported to occur as often as 6 Recently Julieet al revealed in his met analysis that optic nerve sheath diameter ONSD has a good level of diagnostic accuracy for detecting intracranial hypertension with a pooled sensitivity of 09 The central retinal artery CRA is an end artery branch of the internal carotid artery that joins the optic nerve 1cm behind the globe and enters the retina on the optic nerve head Central retinal artery is located inside the optic nerve sheath and The optic nerve is part of the central nervous system and the intraorbital subarachnoid space surrounding the optic nerve is subject to the same pressure changes as the intracranial compartmentso we should expect any increase of ICP will compress the central retinal artery exactly the same as basal cerebral arteries Central retinal artery circulation is low resistance circulation with good diastolic flow and upper limit of resistivity index is 07 So any compression of CRA will decrease the diastolic flow and increase RI Kamilet al studied the blood flow velocity changes in orbital arteries by using Doppler sonography in eight patients with brain death and increased ICP Peak systolic and end-diastolic velocities and resistive indices of the ophthalmic and central retinal arteries were evaluated they observed the absence or reversal of end diastolic blood flow in these arteries If the intracranial pressure is higher than the end-diastolic pressure of the cerebral arteries diastolic flow reversal occurs If the intracranial pressure exceeds systolic pressure blood flow is entirely ceased with complete and irreversible loss of brain function CRA is a superficial easy accessible without bony obstacle like transcranial doppler TCD and the learning curve of its Doppler study can be very steep so it could has a big role in management of cases with increased ICP
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None