Ignite Creation Date:
2024-05-06 @ 7:06 PM
Last Modification Date:
2024-10-26 @ 3:00 PM
Study NCT ID:
NCT05899127
Status:
RECRUITING
Last Update Posted:
2024-01-25
First Post:
2023-02-17
Brief Title:
Relationship Between Lidocaine and Serum Orphanin FQ NOFQ
Sponsor:
Second Hospital of Shanxi Medical University
Organization:
Second Hospital of Shanxi Medical University
Study Overview
Official Title:
Effects of Intravenous Lidocaine Infusion on Stress Response in Patients Undergoing Abdominal Surgery During Perioperative Anesthesia and Its Correlation With Serum Orphanin FQ NOFQ
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The intravenous injection of lidocaine during the perioperative period has been widely used in various types of surgeries Its clinical effect includes reducing stress response during anesthesia decreasing pain and opioid consumption lowering the incidence of postoperative nausea vomiting cognitive dysfunction and reducing the injection pain of propofol However despite the positive impact of lidocaine on surgical patients its mechanism of action remains unclear Serum NOFQ is a neurotransmitter that plays an important role in regulating pain and emotion Therefore this study aims to explore the effects of perioperative intravenous injection of lidocaine on stress responses in surgical patients as well as its mechanism of action and whether Serum NOFQ participates in this process
Detailed Description:
We hypothesize that intravenous injection of lidocaine during the perioperative period can reduce expression of endogenous opioid peptides which in turn can decrease secretion of IL-6 and TNF-α ultimately leading to a reduction in perioperative stress response This randomized controlled trial will be conducted at the Second Hospital of Shanxi Medical University in China with the aim of observing changes in stress-related indicators blood pressure heart rate heart rate variability IL-6 TNF-α as well as Serum NOFQ between patients undergoing abdominal surgery under total intravenous general anesthesia with and without lidocaine injection Lidocaine will be administered as a loading dose during anesthesia induction and continued via infusion until the end of anesthesia maintenance with appropriate depth of anesthesia or BIS readings utilized for monitoring anesthesia depth Routine monitoring parameters including blood pressure heart rate SpO2 and electrocardiogram will be recorded and analyzed Blood samples will be collected 30 minutes before anesthesia induction 1 minute after tracheal intubation and at the end of surgery The use of lidocaine will be evaluated for its impact on perioperative stress response in patients undergoing abdominal surgery with the relationship to changes in levels of endogenous opioid peptides explored
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None