Ignite Creation Date:
2024-05-06 @ 7:05 PM
Last Modification Date:
2024-10-26 @ 3:00 PM
Study NCT ID:
NCT05889897
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-07-18
First Post:
2023-03-26
Brief Title:
Prevalence Risk Factors and Outcomes of Pediatric Vascular Thrombosis
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Prevalence Risk Factors and Outcomes of Vascular Thromboembolism in Children Attending Assuit University Hospital
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is aimed to identify the prevalence risk factors and outcomes of children with either venous or arterial thromboembolism admitted to children hospital Assiut University aiming at early detection and avoidance of catastrophic complications
Detailed Description:
Thrombosis is a blood clot that develops within veins or sometimes arteries in the body
Occur most commonly in the inferior and superior vena cava their major tributaries the deep veins of the extremities the splanchnic veins as well as the cerebral venous sinuses
The incidence of venous thromboembolism VTE increases with age In the pediatric population 0-18 years the incidence is approximately 07-21 cases per 100000 children1-3 while in the adult population the incidence is 100-150 per 1000004
Risk factors include the presence of central venous lines trauma major surgery followed by bedrest immobilization infection cellulitis osteomyelitis phlebitis cancer chemotherapy inflammatory bowel disease nephrotic syndrome obesity dehydration and total parenteral nutrition
Patients with vascular thromboembolism present with various symptoms depending on site of thrombosis symptoms include swelling redness pain low-grade fever In cases that develop pulmonary embolism they experience chest pain and shortness of breath that begin suddenly
Diagnosis of vascular thromboembolism include combination of signs and symptoms together with laboratory investigations that include routine lab investigations D-dimer protein s protein C and antithrombin lll also imaging studies as Doppler US MSCT with angiography and MRV
Vascular thrombosis mainly treated with anticoagulant therapy with subcutaneous injection of low molecular weight heparin These medications prevent the clot from growing and decrease the risk of its breaking apart and causing further complications Other treatments may include wearing compression stockings and applying warm packs to improve blood flow and pain caused by the clot
Occur most commonly in the inferior and superior vena cava their major tributaries the deep veins of the extremities the splanchnic veins as well as the cerebral venous sinuses
The incidence of venous thromboembolism VTE increases with age In the pediatric population 0-18 years the incidence is approximately 07-21 cases per 100000 children1-3 while in the adult population the incidence is 100-150 per 1000004
Risk factors include the presence of central venous lines trauma major surgery followed by bedrest immobilization infection cellulitis osteomyelitis phlebitis cancer chemotherapy inflammatory bowel disease nephrotic syndrome obesity dehydration and total parenteral nutrition
Patients with vascular thromboembolism present with various symptoms depending on site of thrombosis symptoms include swelling redness pain low-grade fever In cases that develop pulmonary embolism they experience chest pain and shortness of breath that begin suddenly
Diagnosis of vascular thromboembolism include combination of signs and symptoms together with laboratory investigations that include routine lab investigations D-dimer protein s protein C and antithrombin lll also imaging studies as Doppler US MSCT with angiography and MRV
Vascular thrombosis mainly treated with anticoagulant therapy with subcutaneous injection of low molecular weight heparin These medications prevent the clot from growing and decrease the risk of its breaking apart and causing further complications Other treatments may include wearing compression stockings and applying warm packs to improve blood flow and pain caused by the clot
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None