Ignite Creation Date:
2024-05-06 @ 7:02 PM
Last Modification Date:
2024-10-26 @ 2:59 PM
Study NCT ID:
NCT05876702
Status:
RECRUITING
Last Update Posted:
2023-05-25
First Post:
2023-05-17
Brief Title:
Endoscopic I-scan Versus Histopathological Evaluation Of Esophageal Lesions
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Endoscopic I-scan Versus Histopathological Evaluation Of Esophageal Lesions
Status:
RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Considering esophageal diseases according to a cross-sectional study of endoscopic findings in patients who underwent upper endoscopy at the Fayoum University Hospital the most common esophageal conditions seen with the endoscope were esophageal varices 256 of cases GERD 238 of cases esophagitis 74 of cases and esophageal monilasis
GERD is characterized by dystressing symptoms and consequences brought on by the reflux of stomach contents Vakil et al 2006It appears that the 2 main GERD phenotypes have different pathophysiological and clinical characteristics In addition the response to antireflux medication varied significantly between NERD and erosive esophagitis Patients with NERD made up the majority of the group with refractory heartburn because they had a noticeably lower response rate to proton pump inhibitor PPI therapy
Barretts oesophagus BO and oesophageal adenocarcinoma may develop as a result of GERD Barretts oesophagus is characterised by intestinal metaplasia which is characterised by acid mucin-containing goblet cells and the replacement of any length of the squamous epithelium in the distal oesophagus by columnar epithelium
Dysphagia is frequently brought on by esophageal cancer which is a serious public health issue In 2003 there were an estimated 13900 new instances of esophageal cancer in the US and 13000 people passed away from the disease Only 13 of people survive five years
High-resolution white-light endoscopy during gastroscopy can identify abnormalities in the mucosa The endoscopist must decide if the aetiology of erosions ulcers strictures or metaplasia is non-neoplastic or cancerous if they are discovered Discoloration a grainy appearance orange peel effect and small lumps and depressions in Barretts layer are indications of dysplasia
The high-definition I-Scan was created by Pentax HOYA Japan and is based on processing the picture captured by the endoscopes CCD charge coupled device to enhance the contrast of the vascular structures and the patterns of the digestive tracts mucosaAndrés Reyes-Dorantes 2011For the situations outlined below some authors advise using the I-Scan modesI-Scan 1 SE thought to be used to find lesions Without affecting the clarity of the endoscopic image it sharpens the image of minute surface defectsthe I-Scan 2 TE plus SE imaging system should be utilized to characterize lesions It increases subtle alterations in the mucosa and vascular architecture while combining surface and tone augmentation and for defining lesions I-Scan 3 TE plus CE should be utilized The margins of the endoscopic image are darkened and blue colour is digitally added
In patients with gastrointestinal diseases endoscopic biopsy and histological evaluation enable early diagnosis of precancerous and cancerous tumours and prompt disease therapyAfzal et al 2006The results of specimens from a study conducted over five years 2004-2008 in the pathology departments of Cairo Universitys faculty of medicine and the Theodor Bilharz Research Institute in Egypt were as follows 5476 of the 210 esophageal specimens had GERD 1761 had Barretts oesophagus 381 had benign lesions 186 had malignant lesions squamous cell carcinoma adenocarcinoma and undifferentiated carcinoma each accounting for 1048 of the total and 524 had other conditions
GERD is characterized by dystressing symptoms and consequences brought on by the reflux of stomach contents Vakil et al 2006It appears that the 2 main GERD phenotypes have different pathophysiological and clinical characteristics In addition the response to antireflux medication varied significantly between NERD and erosive esophagitis Patients with NERD made up the majority of the group with refractory heartburn because they had a noticeably lower response rate to proton pump inhibitor PPI therapy
Barretts oesophagus BO and oesophageal adenocarcinoma may develop as a result of GERD Barretts oesophagus is characterised by intestinal metaplasia which is characterised by acid mucin-containing goblet cells and the replacement of any length of the squamous epithelium in the distal oesophagus by columnar epithelium
Dysphagia is frequently brought on by esophageal cancer which is a serious public health issue In 2003 there were an estimated 13900 new instances of esophageal cancer in the US and 13000 people passed away from the disease Only 13 of people survive five years
High-resolution white-light endoscopy during gastroscopy can identify abnormalities in the mucosa The endoscopist must decide if the aetiology of erosions ulcers strictures or metaplasia is non-neoplastic or cancerous if they are discovered Discoloration a grainy appearance orange peel effect and small lumps and depressions in Barretts layer are indications of dysplasia
The high-definition I-Scan was created by Pentax HOYA Japan and is based on processing the picture captured by the endoscopes CCD charge coupled device to enhance the contrast of the vascular structures and the patterns of the digestive tracts mucosaAndrés Reyes-Dorantes 2011For the situations outlined below some authors advise using the I-Scan modesI-Scan 1 SE thought to be used to find lesions Without affecting the clarity of the endoscopic image it sharpens the image of minute surface defectsthe I-Scan 2 TE plus SE imaging system should be utilized to characterize lesions It increases subtle alterations in the mucosa and vascular architecture while combining surface and tone augmentation and for defining lesions I-Scan 3 TE plus CE should be utilized The margins of the endoscopic image are darkened and blue colour is digitally added
In patients with gastrointestinal diseases endoscopic biopsy and histological evaluation enable early diagnosis of precancerous and cancerous tumours and prompt disease therapyAfzal et al 2006The results of specimens from a study conducted over five years 2004-2008 in the pathology departments of Cairo Universitys faculty of medicine and the Theodor Bilharz Research Institute in Egypt were as follows 5476 of the 210 esophageal specimens had GERD 1761 had Barretts oesophagus 381 had benign lesions 186 had malignant lesions squamous cell carcinoma adenocarcinoma and undifferentiated carcinoma each accounting for 1048 of the total and 524 had other conditions
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None