Ignite Creation Date:
2024-05-06 @ 7:02 PM
Last Modification Date:
2024-10-26 @ 2:59 PM
Study NCT ID:
NCT05874986
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-02-21
First Post:
2023-02-23
Brief Title:
Why do People Respond Differently to Resistance Training
Sponsor:
University of Jyvaskyla
Organization:
University of Jyvaskyla
Study Overview
Official Title:
Precision Exercise PreEx Identifying the Determinants of Inter-individual Variation in Resistance Training Responses
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PreEx
Brief Summary:
It is well known that regular resistance training RT can have health benefits However considerable heterogeneity in RT responses has been observed The mechanisms underlying an individuals ability to respond to RT are mainly unknown but involve a complex network of genomic and non-genomic factors The investigators aim to examine heterogeneity in physiological responses to RT while closely monitoring other environmental factors eg physical activity levels nutrition sleep and stress Participants are healthy sedentary males and females aged 18-50 n400 A controlled 12-week RT intervention will be conducted in two separate data collection periods due to our sample size to characterize RT response Data will be collected before during and after the study period by using measurements of muscle size physical fitness characteristics and body composition as well as by collecting blood samples and questionnaires The investigators will identify the underlying factors contributing to why people differ in their physiological responses to RT For this comprehensive background data will be collected to identify common denominators underlying individual differences in response to RT The investigators will use sophisticated analytical methods to reveal new predictors of training response for different traits This research project aims to gain insight into the sources of individual variation in physiological responses to RT On this basis exercise training can be personalized to optimize the benefits of RT for all individuals Ultimately the investigators will also be able to justify better using RT as part of individualized healthcare strategies in the future
Detailed Description:
The benefits of regular resistance training RT are well acknowledged but it is also well known that tremendous inter-individual variability can be detected in responses to RT The reasons for individual variations in responses to RT is a very complex physiological phenomenon and is still poorly known The individual variation in trainability suggests genetic diversity but also non-genetic determinants potentially contribute significantly to RT responses
The investigators hypothesize that in this study a broad spectrum of adaptive responses to RT are detected By scrutinizing participants backgrounds it can be elucidated why individuals respond differently to regular RT Furthermore it is hypothesized that the investigators can identify specific predictive markers for RT responsiveness That is possible by combining information on training responsiveness with the personal characteristics of the participant
Healthy young adults aged 18-50 will be recruited to the study in two periods to understand the biological basis of heterogeneity in RT responses by minimizing potential age and health-related physiological confounders They are premised to respond positively to the studys primary outcome which is the cross-sectional area CSA of the m vastus lateralis VL To collect comprehensive data the number of participants is maximized within the practical limitations based on our previous and extensive RT studies Therefore of the 400 recruited participants 240 will first undergo 12 weeks of RT data collection I after which 160 participants will perform an RT period with a similar design data collection II Thus an RT period will be conducted in two separate periods for both of these subsamples as 240 is the maximum number of participants that can be supervised with our comprehensive and time-consuming physiological measures within the allocated data collection timeframe Participants comprise an equal proportion of males and females and sex differences in RT responsiveness will be investigated as a secondary aim of the study Combined data collection I and II are referred to as intervention I
The study design of a data collection I is a single-arm trial After assessing eligibility participants engage in the baseline measurements and the 12-week fully supervised RT intervention Additionally we employ a dual-trial -design in data collection II in which the one arm performs a non-RT control period before an RT period whilst the other arm only performs RT Moreover test-retest baseline measurements will be performed in data collection II The RT protocol is similar for both data collections The participants will train two times a week and the program will target all major muscle groups Each training session includes exercises for the lower leg press knee extension and upper body bench press biceps curl and seated row The participants will perform 10 repetitions per set approximately 60-80 of 1RM and three sets per exercise twice per week for the first two weeks as a familiarization After that the training load will be at an 8- to 12-RM zone individualized for each participant for three sets per exercise Loads are increased progressively in each exercise during the RT period using double progression A questionnaire on perceived exertion after each exercise session sRPE will be obtained to evaluate the participants intrinsic effort in performing exercises The training is executed in a local university gym with a standardized time of day and training diaries are used to track the training loads
The measurements are obtained at baseline and after the intervention in data collection I Furthermore mid-measurements are also performed in data collection II Participants are informed of the study goals and are carefully familiarized with study protocols All the tests are carried out at the same time of day The participants are given feedback on their test results during the project In addition to genetics environmental factors are essential in explaining individuality in training responses In this project the investigators focus on gathering comprehensive data on variables of participants background nutrition health status and physical activity that can potentially influence the heterogeneity of RT adaptations
The investigators hypothesize that in this study a broad spectrum of adaptive responses to RT are detected By scrutinizing participants backgrounds it can be elucidated why individuals respond differently to regular RT Furthermore it is hypothesized that the investigators can identify specific predictive markers for RT responsiveness That is possible by combining information on training responsiveness with the personal characteristics of the participant
Healthy young adults aged 18-50 will be recruited to the study in two periods to understand the biological basis of heterogeneity in RT responses by minimizing potential age and health-related physiological confounders They are premised to respond positively to the studys primary outcome which is the cross-sectional area CSA of the m vastus lateralis VL To collect comprehensive data the number of participants is maximized within the practical limitations based on our previous and extensive RT studies Therefore of the 400 recruited participants 240 will first undergo 12 weeks of RT data collection I after which 160 participants will perform an RT period with a similar design data collection II Thus an RT period will be conducted in two separate periods for both of these subsamples as 240 is the maximum number of participants that can be supervised with our comprehensive and time-consuming physiological measures within the allocated data collection timeframe Participants comprise an equal proportion of males and females and sex differences in RT responsiveness will be investigated as a secondary aim of the study Combined data collection I and II are referred to as intervention I
The study design of a data collection I is a single-arm trial After assessing eligibility participants engage in the baseline measurements and the 12-week fully supervised RT intervention Additionally we employ a dual-trial -design in data collection II in which the one arm performs a non-RT control period before an RT period whilst the other arm only performs RT Moreover test-retest baseline measurements will be performed in data collection II The RT protocol is similar for both data collections The participants will train two times a week and the program will target all major muscle groups Each training session includes exercises for the lower leg press knee extension and upper body bench press biceps curl and seated row The participants will perform 10 repetitions per set approximately 60-80 of 1RM and three sets per exercise twice per week for the first two weeks as a familiarization After that the training load will be at an 8- to 12-RM zone individualized for each participant for three sets per exercise Loads are increased progressively in each exercise during the RT period using double progression A questionnaire on perceived exertion after each exercise session sRPE will be obtained to evaluate the participants intrinsic effort in performing exercises The training is executed in a local university gym with a standardized time of day and training diaries are used to track the training loads
The measurements are obtained at baseline and after the intervention in data collection I Furthermore mid-measurements are also performed in data collection II Participants are informed of the study goals and are carefully familiarized with study protocols All the tests are carried out at the same time of day The participants are given feedback on their test results during the project In addition to genetics environmental factors are essential in explaining individuality in training responses In this project the investigators focus on gathering comprehensive data on variables of participants background nutrition health status and physical activity that can potentially influence the heterogeneity of RT adaptations
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None