Ignite Creation Date:
2024-05-06 @ 7:02 PM
Last Modification Date:
2024-10-26 @ 2:59 PM
Study NCT ID:
NCT05879341
Status:
RECRUITING
Last Update Posted:
2023-05-30
First Post:
2023-04-06
Brief Title:
Effect of Gene Polymorphism on Cognitive Function
Sponsor:
Kaohsiung Medical University Chung-Ho Memorial Hospital
Organization:
Kaohsiung Medical University Chung-Ho Memorial Hospital
Study Overview
Official Title:
The Effect of Irisin Polymorphism on Cognitive Function and Inter-individual Exercise Response Variability
Status:
RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to study the effect of gene polymorphism on cognitive improvement in response to exercise in healthy participants The main questions it aims to answer are
To investigate whether FNDC5Irisin genotype polymorphism affects cognitive function and inter-individual variability in exercise response
To explore whether the FNDC5Irisin gene polymorphism can act alone or interact with the BDNF gene to cause inter-individual differences in cognitive function responses to exercise gain
Participants will be asked to perform high-intensity interval training HIIT on a cycle ergometer Each high-intensity training period will be 30 seconds followed by a 4-minute rest period
The participants will also perform cognitive tests Vistorian stroop test and Fitlight trainer test before and after the exercise
To investigate whether FNDC5Irisin genotype polymorphism affects cognitive function and inter-individual variability in exercise response
To explore whether the FNDC5Irisin gene polymorphism can act alone or interact with the BDNF gene to cause inter-individual differences in cognitive function responses to exercise gain
Participants will be asked to perform high-intensity interval training HIIT on a cycle ergometer Each high-intensity training period will be 30 seconds followed by a 4-minute rest period
The participants will also perform cognitive tests Vistorian stroop test and Fitlight trainer test before and after the exercise
Detailed Description:
Exercise has a significant effect on improving brain function It can improve cognitive function enhance learning effects and prevent the occurrence of neurodegenerative diseases in the elderly Exercises mechanism of action to improve cognitive function includes stimulating the nervous system to secrete brain-derived neurotrophic factor BDNF and skeletal muscle to secrete irisin However the effect of exercise on improving physical function varies from person to person This phenomenon is called inter-individual exercise response variability Genetic differences may be responsible for this phenomenon The genotype differences of BDNF and Irisin can cause cognitive function However the scientific community is still unclear whether the differences between the two genotypes are related to individual differences in exercise responses The investigators suspect that genotype might be responsible for interindividual variability in motor responses and therefore designed this experiment to test this thesis This study is expected to recruit 200 healthy adults to complete the genotype sequencing of BDNF and Irisin and use the cognitive function responses before and after a single high-intensity interval aerobic exercise to establish the model that genotype affects the variability of individual exercise responses The experimental results of this study can help the scientific community understand the influence of genotype on individual differences in exercise response and further explore and refine the design of exercise prescription
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None