Ignite Creation Date:
2024-05-06 @ 7:02 PM
Last Modification Date:
2024-10-26 @ 2:58 PM
Study NCT ID:
NCT05861401
Status:
RECRUITING
Last Update Posted:
2023-05-16
First Post:
2023-05-03
Brief Title:
Polymorphism of Janus Kinase 1 and 2 JAK 12 in Patients With Alopecia Areata
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Polymorphism of Janus Kinase 1 and 2 JAK 12 in Patients With Alopecia Areata
Status:
RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Introduction Alopecia areata AA is a complex inflammatory disease characterized by cellular infiltration of T- lymphocytes targeting hair follicles disrupting the anagen phase with spontaneous remission recurrence and exacerbation making it very unpredictable and emotionally disturbing It affects nearly 1-2 of the general population with a lifetime risk of 2 The onset of AA might be at any age however most patients develop the disease before 40 years of age Early-onset AA a mean age of onset at 5-10 years predominantly presents as a more severe subtype such as alopecia universalis Alopecia areata presents clinically as a non-scarring patchy hair loss primarily on the scalp andor other hairy areas and may progress to total scalp hair loss alopecia totalis AT or complete body hair loss alopecia universalis AU Approximately 5- 10 of AA patients will progress into ATAU The course of AA varies greatly the strongest predictors of a poor prognosis include AT AU or ophiasis pattern hair loss as well as earlier age of onset Severe and recurrent AA disturbs quality of life of patients and may also lead to depression changed self-imageand interferes with social activities Currently the hypotheses for AA development mostly focus on the collapse of immune privilege properties of the hair folliclesHFs and the nature of self-antigen presentation follicular antigens that result in the induction and subsequent attack of activated lymphocytes Activation of the lymphocytes mainly CD8NKG2Dinduces release of severalTh1 cytokines interleukin IL-1α IL-1β and tumor necrosis factor TNF alpha capable of inhibiting HF growth with early termination of anagen AA is a polygenic disorder in which several major genes dictate susceptibility to disease up to 28 of patients report at least one affected family member monozygotic twins have exhibited similar times of onset and patterns of hair loss
Genes loci for Human leucocyte antigens HLADRB1 1104 and DQB1 03 are detected in patients with AA The Janus kinases JAKs and signal transducer and activator of transcription STAT JAKSTAT pathway play an important role in inflammatory processes as they are involved in signaling for over 50 cytokines and growth factors The JAKSTAT pathway transduces multiple extracellular signals involved in cell proliferation differentiation migration and apoptosis
The JAK family is constituted by four types of cytoplasmic tyrosine kinases
JAK1 JAK2 JAK3 and TYK2 STAT of which there are seven different subtypes STAT1 STAT2 STAT3 STAT4 STAT5a STAT5b and STAT6 17 is the other fundamental component of the cascade After being phosphorylated by JAK STAT translocates to the nucleus to induce the transcription of specific genes Alterations in the JAKSTAT pathway have been related to the pathophysiology of atopic dermatitis AD vitiligo and AA
Genes loci for Human leucocyte antigens HLADRB1 1104 and DQB1 03 are detected in patients with AA The Janus kinases JAKs and signal transducer and activator of transcription STAT JAKSTAT pathway play an important role in inflammatory processes as they are involved in signaling for over 50 cytokines and growth factors The JAKSTAT pathway transduces multiple extracellular signals involved in cell proliferation differentiation migration and apoptosis
The JAK family is constituted by four types of cytoplasmic tyrosine kinases
JAK1 JAK2 JAK3 and TYK2 STAT of which there are seven different subtypes STAT1 STAT2 STAT3 STAT4 STAT5a STAT5b and STAT6 17 is the other fundamental component of the cascade After being phosphorylated by JAK STAT translocates to the nucleus to induce the transcription of specific genes Alterations in the JAKSTAT pathway have been related to the pathophysiology of atopic dermatitis AD vitiligo and AA
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None