Ignite Creation Date:
2024-05-06 @ 7:01 PM
Last Modification Date:
2024-10-26 @ 2:59 PM
Study NCT ID:
NCT05867901
Status:
RECRUITING
Last Update Posted:
2023-05-31
First Post:
2023-04-23
Brief Title:
Clinical Research of Drug Holiday Based on MRD Detection in GIST Patients at High Risk of Recurrence
Sponsor:
Peking University Peoples Hospital
Organization:
Peking University Peoples Hospital
Study Overview
Official Title:
Clinical Research of Drug Holiday Based on MRD Detection in Gastrointestinal Stromal Tumor Patients at High Risk of Recurrence
Status:
RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is aimed
to evaluate the dynamic monitoring value of MRD detection for postoperative recurrence in high-risk GIST patients
to evaluate the effect of drug holiday mode based on MRD detection on progression-free Survival PFS andor overall survival OS after drug withdrawal for high-risk GIST patients who have achieved disease control after long-term use of imatinib ③ to investigate the response rate of imatinib re-use in patients who developed disease progression after drug withdrawal ④ to explore whether the drug holiday treatment mode based on MRD detection could delay the occurrence of secondary imatinib resistance mutations for high-risk GIST patients with long-term use of imatinib after surgery
to evaluate the dynamic monitoring value of MRD detection for postoperative recurrence in high-risk GIST patients
to evaluate the effect of drug holiday mode based on MRD detection on progression-free Survival PFS andor overall survival OS after drug withdrawal for high-risk GIST patients who have achieved disease control after long-term use of imatinib ③ to investigate the response rate of imatinib re-use in patients who developed disease progression after drug withdrawal ④ to explore whether the drug holiday treatment mode based on MRD detection could delay the occurrence of secondary imatinib resistance mutations for high-risk GIST patients with long-term use of imatinib after surgery
Detailed Description:
Gastrointestinal stromal tumor GIST is the most common mesenchymal tumor of the gastrointestinal tract and surgery is the preferred treatment method for primary resectable GIST The guidelines recommend that patients at high risk of recurrence should be treated with tyrosine kinase inhibitors TKI such as imatinib for at least 3 years after surgery However in actual clinical practice some patients face the situation of early withdrawal or prolonged medication so the timing of drug withdrawal needs to be further studied Recent studies have reported that some GIST patients who have achieved disease control through long-term use of imatinib can still achieve a long progression-free survival after drug withdrawal and those who relapse after drug withdrawal can still achieve disease control after re-use of imatinib This suggests that for some selected patients a drug holiday treatment mode could be possible in which drugs are discontinued when appropriate and restarted if necessary How to select patients suitable for this mode of treatment needs further exploration Liquid biopsy of peripheral blood circulating tumor DNA ctDNA to detect minimal residual disease MRD can be used for the diagnosis efficacy evaluation recurrence and drug resistance monitoring of a variety of malignant tumors Existing studies have explored the drug holiday treatment mode based on MRD detection assisting patients with advanced non-small cell lung cancer to use TKI Therefore this one-arm prospective observational clinical study will assist some high-risk GIST patients who have been treated with imatinib for 3 years after surgery and have achieved disease control to adopt the treatment mode of drug holiday based MRD detection aiming to evaluate the value of MRD detection in monitoring postoperative recurrence of high-risk GIST investigate the effect of drug holiday treatment mode based on MRD detection on disease recurrence and patient survival and to explore whether it can delay the occurrence of drug-resistant mutations
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None