Ignite Creation Date:
2024-05-06 @ 7:01 PM
Last Modification Date:
2024-10-26 @ 2:58 PM
Study NCT ID:
NCT05862675
Status:
WITHDRAWN
Last Update Posted:
2023-07-11
First Post:
2023-02-02
Brief Title:
The Role and Mechanism of Immune Regulation in Acute Lung Injury in Children
Sponsor:
Childrens Hospital of Chongqing Medical University
Organization:
Childrens Hospital of Chongqing Medical University
Study Overview
Official Title:
The Role and Mechanism of Immune Regulation in Acute Lung Injury in Children
Status:
WITHDRAWN
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Due to a time conflict in the research the project research has been temporarily suspended
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute lung injury is a highly prevalent disease in children posing a serious threat to their health and causing economic burden on society and families It has received high attention Blocking the cascade immune inflammatory response that occurs in the respiratory tract and finding key targets for the prevention and treatment of acute lung injury has become an important challenge faced by the medical community The pathogenesis of acute lung injury is complex involving the combined action of multiple cells and cytokines in the immune system Therefore it is necessary to further study the function of immune cells and specific immune pathogenesis providing new ideas and theoretical basis for clinical treatment of acute lung injury The omics technology includes Genomics Transcriptome proteomics metabolomics etc Through qualitative and quantitative analysis of changes in low molecular weight molecules or metabolites of biological samples it provides a new way to find biomarkers and pathogenesis We plan to study the peripheral blood of children with acute lung injury and healthy children and use network analysis to screen for differential genes and related enrichment pathways in acute lung injury We aim to explore the correlation between immune regulation and inflammatory repair in children with acute lung injury and analyze the regulatory mechanisms between immune cells related to it Provide assistance for clinical diagnosis and treatment
Detailed Description:
1 Inclusion criteria of the test group 1 Meeting the specific diagnostic criteria for related lung diseases 2 The factors of lung diseases were infection and sepsis
2 Inclusion criteria of the control group control 1 1 Meeting the specific diagnostic criteria for related lung diseases 2 The factors of lung diseases were non-infectious factors
Control 2 Healthy children
3 Exclusion criteria of the test group 1 Patients with hemodynamic instability Patients with pulmonary hypertension2 Patients with congenital heart disease congenital genetic metabolic disease epilepsy acute and chronic renal insufficiency nephrotic syndrome diabetes et al
4 The collection of clinical data includes name sex age hospitalization number date of hospitalization main diagnosis course of disease main examination and test results medication respiratory support prognosis etc
5 Collect peripheral blood serum sputum or alveolar lavage fluid samples for target sequencing
2 Inclusion criteria of the control group control 1 1 Meeting the specific diagnostic criteria for related lung diseases 2 The factors of lung diseases were non-infectious factors
Control 2 Healthy children
3 Exclusion criteria of the test group 1 Patients with hemodynamic instability Patients with pulmonary hypertension2 Patients with congenital heart disease congenital genetic metabolic disease epilepsy acute and chronic renal insufficiency nephrotic syndrome diabetes et al
4 The collection of clinical data includes name sex age hospitalization number date of hospitalization main diagnosis course of disease main examination and test results medication respiratory support prognosis etc
5 Collect peripheral blood serum sputum or alveolar lavage fluid samples for target sequencing
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None