Ignite Creation Date:
2024-05-06 @ 7:00 PM
Last Modification Date:
2024-10-26 @ 2:58 PM
Study NCT ID:
NCT05862896
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-05-17
First Post:
2023-05-16
Brief Title:
Exploring Gas Transfer and the Utility of Dynamic Chest Radiography in Long Covid Patients
Sponsor:
Liverpool University Hospitals NHS Foundation Trust
Organization:
Liverpool University Hospitals NHS Foundation Trust
Study Overview
Official Title:
Exploring Gas Transfer and the Utility of Dynamic Chest Radiography in Long Covid Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LoCTDC
Brief Summary:
This study aims to identify if breathless patients with Long COVID have reduced transfer factor on pulmonary function testing and if the degree of transfer factor reduction is correlated with the symptom severity and physiological ability to exercise We will also investigate whether a new type of X-ray called a dynamic chest X-ray can identify perfusion abnormalities and whether these correlate with differences in diffusion capacity measured on a pulmonary function test
Detailed Description:
Long COVID is the term used to describe patients who present with persistent symptoms after recovering from SARS-CoV-2 infection Patients exhibit a range of symptoms and commonly report respiratory and cardiac phenomena including breathlessness feeling tight chested and having persistent tachycardias Survey data suggests up to 87 of patients discharged from hospital after COVID-19 infection have ongoing symptoms 60 days after discharge with 43 describing breathlessness In the USA 35 of patients treated for SARS-CoV-2 as an outpatient have ongoing symptoms with a similar percentage of the population unable to return to their normal work The natural history and pathophysiology of long COVID is not yet fully understood Few studies have explored pulmonary function in post-COVID patients There are suggestions that functional limitation is related to lung abnormalities affecting both ventilation air flow and perfusion blood flow possibly caused by micro-blood clots Establishing a relatively cost-effective and accessible way of diagnosing these will allow clinicians to treat or signpost the patients to the correct services This is vital at both the patient and health system level
Full pulmonary function testing is routinely done in respiratory clinics to investigate breathlessness and diagnose conditions such as asthma chronic obstructive pulmonary disease COPD and pulmonary fibrosis It includes a measure of transfer factor an estimate of the efficiency of the diffusion of gas from the lung into the blood stream The lungs ability to absorb carbon monoxide CO is measured as a proxy for the ability to absorb oxygen It is hypothesised that long COVID patients with breathlessness have abnormal gas transfer due to lung tissue damage at an alveolar level andor perfusion abnormalities such as micro clots Dynamic X-ray is a new innovative technology to image the thoracic cavity throughout the breathing cycle allowing assessment of pulmonary function and possibly diagnose small ventilation-perfusion abnormities Liverpool hosts the only dynamic X-ray machine in Europe Potential applications beyond COVID are numerous including filling diagnostic gaps in many lung diseases where expensive lung function testing is an unrealistic possibility in the medium term
Full pulmonary function testing is routinely done in respiratory clinics to investigate breathlessness and diagnose conditions such as asthma chronic obstructive pulmonary disease COPD and pulmonary fibrosis It includes a measure of transfer factor an estimate of the efficiency of the diffusion of gas from the lung into the blood stream The lungs ability to absorb carbon monoxide CO is measured as a proxy for the ability to absorb oxygen It is hypothesised that long COVID patients with breathlessness have abnormal gas transfer due to lung tissue damage at an alveolar level andor perfusion abnormalities such as micro clots Dynamic X-ray is a new innovative technology to image the thoracic cavity throughout the breathing cycle allowing assessment of pulmonary function and possibly diagnose small ventilation-perfusion abnormities Liverpool hosts the only dynamic X-ray machine in Europe Potential applications beyond COVID are numerous including filling diagnostic gaps in many lung diseases where expensive lung function testing is an unrealistic possibility in the medium term
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None