Ignite Creation Date:
2024-05-06 @ 7:00 PM
Last Modification Date:
2024-10-26 @ 2:59 PM
Study NCT ID:
NCT05864729
Status:
COMPLETED
Last Update Posted:
2024-03-26
First Post:
2023-05-08
Brief Title:
The Association Between Systemic Microvascular Endothelial Function and Coronary Physiology Indexes
Sponsor:
National Institute of Cardiology Laranjeiras Brazil
Organization:
National Institute of Cardiology Laranjeiras Brazil
Study Overview
Official Title:
Correlation Between Physiological Measures of Ischemia in the Hemodynamics Laboratory and Systemic Microcirculatory Parameters in Patients With Intermediate Lesions of the Main Coronary Arteries
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The present study evaluates skin microvascular reactivity and coronary physiology in the same coronary artery disease CAD patients
This study is expected to find associations between systemic microvascular reactivity measured non-invasively at the skin surface and coronary reserve evaluated by the invasive angiographic method
This study is expected to find associations between systemic microvascular reactivity measured non-invasively at the skin surface and coronary reserve evaluated by the invasive angiographic method
Detailed Description:
Introduction Microvascular reactivity MR evaluated in the skin has been proposed as representative of systemic endothelial function including coronary circulation There is a lack of studies investigating the association between skin MR and invasive evaluation of coronary reserve Objective To evaluate skin MR and coronary physiology in the same coronary artery disease CAD patients Methods Transversal study recruiting adult patients with indication for elective coronary angiographic study for the evaluation of CAD by an independent medical team The evaluation of microvascular cutaneous blood flow of the forearm will use laser speckle contrast imaging LSCI coupled with acetylcholine iontophoresis Coronary physiology will be evaluated in the same patients and in the same day with coronary angiography with lesion assessment by fractional flow reserve FFR after intracoronary adenosine administration and contrast fractional flow reserve cFFR after intracoronary contrast media administration with measurements of hyperemic intravascular pressures FFR and cFFR will be performed in vessels with intermediate lesions as evaluated in quantitative angiography Expected results This study is expected to find associations between systemic MR measured non-invasively at the skin surface and coronary reserve evaluated by the invasive angiographic method
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None