Ignite Creation Date:
2024-05-06 @ 7:00 PM
Last Modification Date:
2024-10-26 @ 2:58 PM
Study NCT ID:
NCT05862311
Status:
COMPLETED
Last Update Posted:
2023-05-17
First Post:
2023-04-16
Brief Title:
The Effect of Non-Surgical Periodontal Treatment on Bone Metabolism in Type 2 Diabetes and Systemically Healthy Individuals
Sponsor:
Necmettin Erbakan University
Organization:
Necmettin Erbakan University
Study Overview
Official Title:
The Effect of Non-Surgical Periodontal Therapy on Sclerostin Irisin RANKL OPG IL-6 and TNF-α Levels in Type 2 Diabetes and Systemically Healthy Individuals
Status:
COMPLETED
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study it was concluded that sclerostin and irisin may be alternative markers for evaluating the effectiveness of periodontal treatment and healing of periodontal tissues by affecting bone metabolism
Detailed Description:
Background Diabetes and periodontitis are chronic inflammatory diseases with similar pathogenesis and clinical and immunological interrelationships The aim of this study is to determine periodontal clinical parameters and sclerostin irisin Receptor Activator of Nuclear Factor κB Ligand RANKLOsteoprotegerin OPG interleukin-6 IL-6 and tumor necrosis factor-α TNF-α levels in gingival crevicular fluid GCF in individuals with type 2 diabetes and systemically healthy periodontitis and to evaluate the effect of non-surgical periodontal therapy on these clinical parameters and biomarkers
Method Within the scope of this study applying to Necmettin Erbakan University Faculty of Dentistry Periodontology Clinic A total of 50 individuals including 25 patients with type 2 diabetes and periodontitis DMP group and 25 patients with systemically healthy and periodontitis SSP group were included in the study After recording the clinical periodontal parameters gingival index GI plaque index PI probing pocket depth PPD clinical attachment level CAL of each individual included in the study GCF samples were obtained and non-surgical periodontal therapy were completed The individuals were invited to the controls 3 months later and the procedures for clinical periodontal measurements and DOS samples collection were repeated Levels of biomarkers in DOS samples were determined by ELISA Enzyme Linked Immunosorbent Assay method
Method Within the scope of this study applying to Necmettin Erbakan University Faculty of Dentistry Periodontology Clinic A total of 50 individuals including 25 patients with type 2 diabetes and periodontitis DMP group and 25 patients with systemically healthy and periodontitis SSP group were included in the study After recording the clinical periodontal parameters gingival index GI plaque index PI probing pocket depth PPD clinical attachment level CAL of each individual included in the study GCF samples were obtained and non-surgical periodontal therapy were completed The individuals were invited to the controls 3 months later and the procedures for clinical periodontal measurements and DOS samples collection were repeated Levels of biomarkers in DOS samples were determined by ELISA Enzyme Linked Immunosorbent Assay method
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None