Ignite Creation Date:
2024-05-06 @ 6:59 PM
Last Modification Date:
2024-10-26 @ 2:58 PM
Study NCT ID:
NCT05851560
Status:
RECRUITING
Last Update Posted:
2023-07-05
First Post:
2023-04-17
Brief Title:
Prospective Comparison of the Effect on Antiadhesive Barriers During Thyroid or Parathyroid Surgery
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Prospective Comparison of the Effect on Antiadhesive Barriers During Thyroid or Parathyroid Surgery
Status:
RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Despite use of meticulous surgical techniques and regardless of surgical access via conventional open or endoscopy postoperative adhesions develop in the vast majority of patients undergoing neck surgery Such adhesions represent not only adhesion reformation at sites of adhesiolysis but also de novo adhesion formation at sites of surgical procedures Improved understanding of the pathophysiology of adhesion development and distinguishing variations in the molecular biologic mechanisms represent future opportunities to improve the reduction of postoperative adhesions
After surgical tissue injury there were local release of histamine cytokines and growth factors that lead to adhesion development Other than survival or safety issues cosmetics concerns and quality of life are the motifs after thyroid surgeries currently Pos-thyroidectomy adhesions include various symptoms such as neck discomfort neck tightness skin adhesion to the trachea skin scarring from adhesive reaction and vocal cord palsy or impairment of laryngeal vertical movement Relief of the adhesion through wound massage or anti-adhesion agents could reduce neck discomfort and voice changesAlthough oxidized regenerated cellulose ORC and hyaluronic acid HA appeared to be safe and effective to decrease the incidence of adhesions to improve adhesion-related neck discomfort and to prevent skin adhesion to the trachea after neck surgery The application of antiadhesive barriers after neck surgery is safe but the effect is still uncertain Thus we aim to confirm the antiadhesive effect of multiple antiadhesive barriers in thyroidparathyroid surgery
After surgical tissue injury there were local release of histamine cytokines and growth factors that lead to adhesion development Other than survival or safety issues cosmetics concerns and quality of life are the motifs after thyroid surgeries currently Pos-thyroidectomy adhesions include various symptoms such as neck discomfort neck tightness skin adhesion to the trachea skin scarring from adhesive reaction and vocal cord palsy or impairment of laryngeal vertical movement Relief of the adhesion through wound massage or anti-adhesion agents could reduce neck discomfort and voice changesAlthough oxidized regenerated cellulose ORC and hyaluronic acid HA appeared to be safe and effective to decrease the incidence of adhesions to improve adhesion-related neck discomfort and to prevent skin adhesion to the trachea after neck surgery The application of antiadhesive barriers after neck surgery is safe but the effect is still uncertain Thus we aim to confirm the antiadhesive effect of multiple antiadhesive barriers in thyroidparathyroid surgery
Detailed Description:
The postsurgical adhesions remain a significant cause of morbidity for a large number of patients in thyroid and parathyroid surgeries despite use of meticulous surgical techniques and regardless of surgical access via conventional open or endoscopy Such adhesions represent not only adhesion reformation at sites of adhesiolysis but also de novo adhesion formation at sites of surgical procedures A number of products in the form of film or fluid are used to prevent postoperative adhesion formation These products normally serve as barriers to separate the contact of the damaged tissue surfaces in many animal models and some clinical practices However there are few evidences for surgeons to use or no use or choose the suitable products in their clinical practice in neck surgeries Improved understanding of the pathophysiology of adhesion development and distinguishing variations in the molecular biologic mechanisms represent future opportunities to improve the reduction of postoperative adhesions
After surgical tissue injury there were local release of histamine cytokines and growth factors that lead to adhesion development Local tissue inflammation processes initiate capillary leakage of serosanguineous fluid including clotting factors and recruitment of macrophages and other cells including fibroblasts Cutting fulguration ligation of the macrovasculature and microvasculature leads to a state of tissue hypoxemia Along with the accumulation of metabolic byproducts such as lactic acid the lowering the pH of the injured tissue and the conversion from aerobic to anaerobic metabolism within the injured tissues Tissue hypoxia also results in creation of oxidative stress with production of oxygen and nitrogen free radicals which can result in DNA mutations alterations of mitochondrial DNA and generation of oxidized proteins
Subsequently induce lipid peroxidation and protein nitration The known factors involved in the inflammatory-like response that lead to adhesion development are type 1 collagen transforming growth factor b1 TGF-b1 tumor necrosis factor a TNF-a interleukin 6 IL-6 and vascular endothelial growth factor VEGF Of note the scavenging of free radicals such as superoxide by superoxide dismutase can prevent the development of the adhesion phenotype Other processes affected include plasminogen activator activity PAA a function of tissue plasminogen activator and its inhibitor plasminogen activator inhibitor-1 metalloproteinase activity and extracellular matrix deposition such as collagen 1 collagen 3 and fibronectin There is also initiation of processes leading to angiogenesis which can lead to new vessel formation that could resupply oxygen to these tissues as well as remove metabolic byproducts
After surgical tissue injury there were local release of histamine cytokines and growth factors that lead to adhesion development Local tissue inflammation processes initiate capillary leakage of serosanguineous fluid including clotting factors and recruitment of macrophages and other cells including fibroblasts Cutting fulguration ligation of the macrovasculature and microvasculature leads to a state of tissue hypoxemia Along with the accumulation of metabolic byproducts such as lactic acid the lowering the pH of the injured tissue and the conversion from aerobic to anaerobic metabolism within the injured tissues Tissue hypoxia also results in creation of oxidative stress with production of oxygen and nitrogen free radicals which can result in DNA mutations alterations of mitochondrial DNA and generation of oxidized proteins
Subsequently induce lipid peroxidation and protein nitration The known factors involved in the inflammatory-like response that lead to adhesion development are type 1 collagen transforming growth factor b1 TGF-b1 tumor necrosis factor a TNF-a interleukin 6 IL-6 and vascular endothelial growth factor VEGF Of note the scavenging of free radicals such as superoxide by superoxide dismutase can prevent the development of the adhesion phenotype Other processes affected include plasminogen activator activity PAA a function of tissue plasminogen activator and its inhibitor plasminogen activator inhibitor-1 metalloproteinase activity and extracellular matrix deposition such as collagen 1 collagen 3 and fibronectin There is also initiation of processes leading to angiogenesis which can lead to new vessel formation that could resupply oxygen to these tissues as well as remove metabolic byproducts
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None