Ignite Creation Date:
2024-05-06 @ 6:58 PM
Last Modification Date:
2024-10-26 @ 2:58 PM
Study NCT ID:
NCT05852964
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-05-10
First Post:
2023-05-02
Brief Title:
Inflammatory and Anti-Inflammatory Gene Expressions in Liver Transplant Patients
Sponsor:
Inonu University
Organization:
Inonu University
Study Overview
Official Title:
Investigation of Inflammatory and Anti-Inflammatory Gene Expressions in Liver Transplant Patients Before and After the Operation
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In our study some inflammatory Interleukin-2 Interleukin-6 Interferon-γ Tumor Necrosis Factor-α and anti-inflammatory Interleukin-4 and Interleukin-10 cytokine genes expressions and Triggering Receptor Expressed On Myeloid Cells- 1 which contributes to the pathology of acute and chronic inflammatory diseases Human Leukocyte Antigen-G5 which suppresses the immune response the expression levels of transcription factor Forkhead box-P3 expressed in regulatory T-lymphocytes and Cluster of Differentiation CD14 genes which are thought to be biomarkers in various infectious diseases and expressed in monocytes will be measured from peripheral blood samples obtained from liver transplant patients before 1 month and 6 months after the operation In addition the classical liver markers Aspartate Aminotransferase AST Alanine Aminotransferase ALT Platelet Count PLT Alpha Feto Protein AFP Direct Bilirubin Bilirubin D Total Bilirubin Bilirubin T and C- Levels of biochemical parameters such as Reactive Protein CRP will be measured In the light of the data to be obtained it is aimed to find biomarkers with high predictive value for rejection and infection after liver transplantation
Detailed Description:
Liver transplantation is the transplantation of the liver which is completely or partially removed by surgical intervention from a living or brain-dead cadaver to the recipient Today organ transplantation procedures are carried out successfully in many centers in our countryLiver transplantation has become the most effective treatment method for acute and chronic liver failure due to different reasonsThe life expectancy of individuals with advanced liver disease which was limited to months before liver transplantation was extended with liver transplantation and the quality of life was improved with this treatment method However since most of the organ transplants are made from genetically different donors tissue compatibility between the donor and the recipient remains a problemTherefore the recipients immune response to donor graft antigens should be considered
In recent years the application of advanced surgery and new immunosuppressive approaches has made it possible to successfully transplant almost any vital organ or tissue However due to both infection and genetic factors an immune response to the donor organ may develop and cause organ rejection At this point we think that early diagnosis and discovery of immune response parameters that distinguish infection from rejection may be importantIn our study some inflammatory Interleukin-2 Interleukin-6 Interferon-γ Tumor Necrosis Factor-α and anti-inflammatory Interleukin-4 and Interleukin-10 cytokine genes expressions and Triggering Receptor Expressed on Myeloid Cells-1 which contributes to the pathology of acute and chronic inflammatory diseases Human Leukocyte Antigen-G5 which suppresses the immune response the expression levels of transcription factor Forkhead box-P3 expressed in regulatory T-lymphocytes and Cluster of Differentiation CD14 genes which are thought to be biomarkers in various infectious diseases and expressed in monocytes will be measured from peripheral blood samples obtained from liver transplant patients before 1 month and 6 months after the operation In addition the classical liver markers Aspartate Aminotransferase AST Alanine Aminotransferase ALT Platelet Count PLT Alpha Feto Protein AFP Direct Bilirubin Bilirubin D Total Bilirubin Bilirubin T and C- Levels of biochemical parameters such as Reactive Protein CRP will be measured In the light of the data to be obtained it is aimed to find biomarkers with high predictive value for rejection and infection after liver transplantation
In recent years the application of advanced surgery and new immunosuppressive approaches has made it possible to successfully transplant almost any vital organ or tissue However due to both infection and genetic factors an immune response to the donor organ may develop and cause organ rejection At this point we think that early diagnosis and discovery of immune response parameters that distinguish infection from rejection may be importantIn our study some inflammatory Interleukin-2 Interleukin-6 Interferon-γ Tumor Necrosis Factor-α and anti-inflammatory Interleukin-4 and Interleukin-10 cytokine genes expressions and Triggering Receptor Expressed on Myeloid Cells-1 which contributes to the pathology of acute and chronic inflammatory diseases Human Leukocyte Antigen-G5 which suppresses the immune response the expression levels of transcription factor Forkhead box-P3 expressed in regulatory T-lymphocytes and Cluster of Differentiation CD14 genes which are thought to be biomarkers in various infectious diseases and expressed in monocytes will be measured from peripheral blood samples obtained from liver transplant patients before 1 month and 6 months after the operation In addition the classical liver markers Aspartate Aminotransferase AST Alanine Aminotransferase ALT Platelet Count PLT Alpha Feto Protein AFP Direct Bilirubin Bilirubin D Total Bilirubin Bilirubin T and C- Levels of biochemical parameters such as Reactive Protein CRP will be measured In the light of the data to be obtained it is aimed to find biomarkers with high predictive value for rejection and infection after liver transplantation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None