Ignite Creation Date:
2024-05-06 @ 6:58 PM
Last Modification Date:
2024-10-26 @ 2:57 PM
Study NCT ID:
NCT05843435
Status:
RECRUITING
Last Update Posted:
2024-05-16
First Post:
2023-04-24
Brief Title:
Brain Connectivity Between Networks Implied in Inhibition and Cue-reactivity in Alcohol Use Disorder
Sponsor:
University of Bern
Organization:
University of Bern
Study Overview
Official Title:
Brain Connectivity Between Networks Implied in Inhibition and Cue-reactivity in Alcohol Use Disorder
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NIQA
Brief Summary:
Research about patients with alcohol use disorder has shown that task-related brain activation patterns as well as resting-state connectivity measured with functional magnetic resonance imaging change with clinical parameters such as the extent of craving and duration of abstinence during treatment These brain activation alterations are related to treatment success Although an imbalance between increased cue-reactivity and impaired counteracting inhibitory control processes are at the core of most neuropsychological conceptualizations of alcohol use disorder the direct interaction between these two processes has not yet been investigated Therefore the investigators aim to study patients with alcohol use disorder in an ultra-high-field 7 Tesla magnetic resonance imaging scanner to identify fine-grained activation and connectivity patterns The investigators would like to improve the knowledge of the interplay between the brain networks for inhibition and cue-reactivity as well as to explore its influence on craving and treatment success The investigators hypothesize that a more pronounced negative relationship between increased cue-reactivity and reduced inhibitory control processes in the brain is linked to higher craving and worse relapse probability
Detailed Description:
Even if an imbalance between enhanced cue-reactivity and impaired opposing control processes is at the center of most neuroscientific conceptualizations of alcohol use disorder AUD these two processes are still rarely investigated in direct interaction
Attempting to target both processes in one design initial studies reported enhanced brain activation in anterior cingulate cortex ACC and ventrolateral prefrontal cortex vlPFC when control processes had to be carried out in the context of alcohol-related cues and linked this altered brain activation to relapse risk Hence the proposed study will take advantage of the higher spatial resolution and signal-to-noise ratio of a 7 Tesla fMRI scanner to investigate more subtle effects and the involvement of subregions of vlPFC and ACC during alcohol-related inhibition
Of special interest particularly when it comes to explaining an imbalance between brain systems related to cue-reactivity and inhibitory control are concurrent measures of functional brain connectivity Aberrant resting-state functional connectivity in networks involved in reward prediction motivation salience attribution and executive control have been reported in AUD Also altered task-related connectivity was observed during cue-reactivity as well as during executive control However functional connectivity measures during a task combining both aspects are still missing Therefore this study examines the mutual interplay between cue-responsive regions and opposing inhibitory control networks To this aim task-related functional connectivity are measured in a specifically tailored experimental design allowing for the assessment of effects related to cue-reactivity inhibition as well as their interaction
Besides this study assesses whether possible interaction effects of task-related functional connectivity between cue-reactivity and inhibitory control vary with craving change with prolonged abstinence or predicts drinking outcome
Taken together this study will deepen the understanding of the interplay between neuronal networks central to AUD cue-reactivity and inhibitory control The imbalance between these processes is crucial for recently abstinent patients striving to control drinking habits and urges in an environment infused with alcohol-related cues As such markers capturing the interaction between these processes are of high conceptual and clinical relevance and might pave the way towards a potential biomarker indicating enhanced relapse risk
Attempting to target both processes in one design initial studies reported enhanced brain activation in anterior cingulate cortex ACC and ventrolateral prefrontal cortex vlPFC when control processes had to be carried out in the context of alcohol-related cues and linked this altered brain activation to relapse risk Hence the proposed study will take advantage of the higher spatial resolution and signal-to-noise ratio of a 7 Tesla fMRI scanner to investigate more subtle effects and the involvement of subregions of vlPFC and ACC during alcohol-related inhibition
Of special interest particularly when it comes to explaining an imbalance between brain systems related to cue-reactivity and inhibitory control are concurrent measures of functional brain connectivity Aberrant resting-state functional connectivity in networks involved in reward prediction motivation salience attribution and executive control have been reported in AUD Also altered task-related connectivity was observed during cue-reactivity as well as during executive control However functional connectivity measures during a task combining both aspects are still missing Therefore this study examines the mutual interplay between cue-responsive regions and opposing inhibitory control networks To this aim task-related functional connectivity are measured in a specifically tailored experimental design allowing for the assessment of effects related to cue-reactivity inhibition as well as their interaction
Besides this study assesses whether possible interaction effects of task-related functional connectivity between cue-reactivity and inhibitory control vary with craving change with prolonged abstinence or predicts drinking outcome
Taken together this study will deepen the understanding of the interplay between neuronal networks central to AUD cue-reactivity and inhibitory control The imbalance between these processes is crucial for recently abstinent patients striving to control drinking habits and urges in an environment infused with alcohol-related cues As such markers capturing the interaction between these processes are of high conceptual and clinical relevance and might pave the way towards a potential biomarker indicating enhanced relapse risk
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None