Ignite Creation Date:
2024-05-06 @ 6:58 PM
Last Modification Date:
2024-10-26 @ 2:57 PM
Study NCT ID:
NCT05840536
Status:
WITHDRAWN
Last Update Posted:
2023-05-03
First Post:
2014-04-22
Brief Title:
Combination Diuretic Therapy for Acute Decompensated Heart Failure
Sponsor:
Ochsner Health System
Organization:
Ochsner Health System
Study Overview
Official Title:
Efficacy and Tolerability of Combination Intravenous Diuretic Therapy Versus Intravenous Loop Diuretic Therapy Alone for the Treatment of Acute Decompensated Heart Failure
Status:
WITHDRAWN
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COMBIND-HF
Brief Summary:
Patients with heart failure are often admitted to the hospital because they have accumulated excessive amounts of fluid they become short of breath and congested with fluid Removing the excess fluid is necessary to improve the patients symptoms and reduce the risk of being re-admitted to the hospital Diuretics water pills are often given through an IV to accelerate the fluid removal Furosemide is commonly used for fluid removal however some patients do not respond well to the medication There are other diuretics available that can work in conjunction with furosemide and increase the rate of fluid removal The other water pills have slightly different mechanisms of action in the body compared to furosemide and when combined they may increase fluid removal
The investigators hypothesize that adding chlorothiazide to furosemide will result in quicker and more effective fluid removal in heart failure patients
The investigators hypothesize that adding chlorothiazide to furosemide will result in quicker and more effective fluid removal in heart failure patients
Detailed Description:
The investigators will randomly assign patients to receive either furosemide alone or furosemide in combination with chlorothiazide when they are admitted to the hospital with acute heart failure and excessive volume
All patients will be monitored for rate of fluid removal improvement in symptoms and side-effects of the medications
All patients will be monitored for rate of fluid removal improvement in symptoms and side-effects of the medications
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None