Ignite Creation Date:
2024-05-06 @ 6:58 PM
Last Modification Date:
2024-10-26 @ 2:58 PM
Study NCT ID:
NCT05846191
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-05-06
First Post:
2023-04-26
Brief Title:
Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients With Gestational Diabetes Mellitus in Second Trimester of Pregnancy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients With Gestational Diabetes Mellitus in Second Trimester of Pregnancy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 To assess the value of serum Pentraxin-3 and high sensitive CRP in females with normal pregnancy and females with gestational diabetes mellitus in second trimester of pregnancy
2 To study correlations between serum Pentraxin-3 and High sensitive CRP in gestational diabetes
2 To study correlations between serum Pentraxin-3 and High sensitive CRP in gestational diabetes
Detailed Description:
Gestational diabetes mellitus GDM refers to abnormal glucose metabolism that occurs or is discovered during pregnancy it can cause multiple poor outcomes and increase maternal and child prevalence and mortality
GDM can increase the risk of type 2 diabetes mellitus T2DM and cardiovascular diseases in pregnant women and the risk of metabolic disorders in their offspring is high so its called a disease that affects two generations1 The relationship between maternal hyperglycemia and fetal macrosomia together with other complications has been confirmed2 Women with GDM have a higher long-term risk of type 2 diabetes mellitus3 Pentraxin 3 PTX3 and high sensitive CRP are both the acute phase proteins belonging to the pentraxin family but with different biological characteristics CRP belongs to the short PTX which is an acute phase protein synthesized by the hepatocytes when the body is stimulated by microbial invasion or tissue damage4 PTX3 is a long-chain PTX protein A variety of tissue cells can produce PTX3 under the stimulation of pro-inflammatory factors including the endothelial cells fibroblasts monocytes adipocytes etc56 There is one studyChanges of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus 2019 that has come to PTX3 and hs-CRP may be related to the pathogenesis of GDM and they are significantly increased in the second trimester which provides a new idea for early prevention and treatment of GDM
GDM can increase the risk of type 2 diabetes mellitus T2DM and cardiovascular diseases in pregnant women and the risk of metabolic disorders in their offspring is high so its called a disease that affects two generations1 The relationship between maternal hyperglycemia and fetal macrosomia together with other complications has been confirmed2 Women with GDM have a higher long-term risk of type 2 diabetes mellitus3 Pentraxin 3 PTX3 and high sensitive CRP are both the acute phase proteins belonging to the pentraxin family but with different biological characteristics CRP belongs to the short PTX which is an acute phase protein synthesized by the hepatocytes when the body is stimulated by microbial invasion or tissue damage4 PTX3 is a long-chain PTX protein A variety of tissue cells can produce PTX3 under the stimulation of pro-inflammatory factors including the endothelial cells fibroblasts monocytes adipocytes etc56 There is one studyChanges of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus 2019 that has come to PTX3 and hs-CRP may be related to the pathogenesis of GDM and they are significantly increased in the second trimester which provides a new idea for early prevention and treatment of GDM
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None