Ignite Creation Date:
2024-05-06 @ 6:58 PM
Last Modification Date:
2024-10-26 @ 2:57 PM
Study NCT ID:
NCT05841199
Status:
RECRUITING
Last Update Posted:
2023-11-08
First Post:
2023-03-23
Brief Title:
Coronary Flow During Rapid Heart Rates
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
Coronary Epicardial and Microcirculatory Determinants of Ventricular Tachycardia Tolerability
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
VT flow
Brief Summary:
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia VT is tolerated The main questions it aims to answer are
1 What impact does coronary artery disease have on the ability for a patient to tolerate VT
2 Does treatment of coronary artery disease with stents improve the tolerability of VT
Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure coronary pressure and coronary flow made during pacing at a range of heart rates
1 What impact does coronary artery disease have on the ability for a patient to tolerate VT
2 Does treatment of coronary artery disease with stents improve the tolerability of VT
Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure coronary pressure and coronary flow made during pacing at a range of heart rates
Detailed Description:
Ventricular tachycardia VT is a common and life-threatening arrhythmia that occurs in people with heart problems Some patients who develop this arrhythmia remain very stable with very little symptoms while others become unstable with low blood pressure or even sudden death It is not known why some people tolerate the arrhythmia well and others do not
If VT is not tolerated then current practice is to offer an implantable cardioverter defibrillator ICD which can deliver a shock to the heart if dangerous heart rhythms are detected While shocks can be life-saving they are also harmful including causing psychological distress ICDs also frequently deliver shocks when they are not needed
If research could identify which factors predispose a person to be stable or unstable in VT this would allow doctors to help them in a range of ways One way would be to treat patients to improve the tolerance of VT so avoiding the need for an ICD Another would be to assess the the risk of instability and so allow a patient-centred decision on whether an ICD is needed
In this study the investigators plan to recruit patients who are referred for a coronary angiogram During the angiogram the investigators will stimulate the heart at a range of fast heart rates and measure their blood pressure and flow in their coronary arteries In patients who undergo stenting for a coronary stenosis the investigators will also make these measurements after stenting so they can see if there is any difference By recruiting a range of different cardiology patients the investigators will be able to assess which factors contribute to stability during VT
If VT is not tolerated then current practice is to offer an implantable cardioverter defibrillator ICD which can deliver a shock to the heart if dangerous heart rhythms are detected While shocks can be life-saving they are also harmful including causing psychological distress ICDs also frequently deliver shocks when they are not needed
If research could identify which factors predispose a person to be stable or unstable in VT this would allow doctors to help them in a range of ways One way would be to treat patients to improve the tolerance of VT so avoiding the need for an ICD Another would be to assess the the risk of instability and so allow a patient-centred decision on whether an ICD is needed
In this study the investigators plan to recruit patients who are referred for a coronary angiogram During the angiogram the investigators will stimulate the heart at a range of fast heart rates and measure their blood pressure and flow in their coronary arteries In patients who undergo stenting for a coronary stenosis the investigators will also make these measurements after stenting so they can see if there is any difference By recruiting a range of different cardiology patients the investigators will be able to assess which factors contribute to stability during VT
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None