Ignite Creation Date:
2024-05-06 @ 6:58 PM
Last Modification Date:
2024-10-26 @ 2:57 PM
Study NCT ID:
NCT05843019
Status:
RECRUITING
Last Update Posted:
2023-06-22
First Post:
2023-04-24
Brief Title:
Adherence in Global Airways - Steroid Intake and Effects on Chronic Rhinosinosinutis
Sponsor:
Christiane Haase
Organization:
Rigshospitalet Denmark
Study Overview
Official Title:
Adherence in Global Airways - the Relationship Between Steroid Intake and the Impact on the Endocrine Axis Bone Density and Structure in Patients With Chronic Sinusitis and Asthma
Status:
RECRUITING
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AGAS 2023
Brief Summary:
The purpose of this study is to investigate the relationship between long-term use of systemic steroids in patients with upper and lower respiratory tract diseases and their own production of cortisol cross-sectional as well as whether those with low cortisol levels have an impact on bone density As patients with CRSwNP have a high use of steroids they routinely undergo a DEXA scan at the Respiratory Clinic Department of Ear-Nose-Throat Surgery and Audiology ENT - Rigshospitalet RH to examine whether their bone density and structure are affected The scan will be included as a clinical secondary outcome to assess whether systemic steroid use has an impact on this
The purpose of the study is therefore to compare steroid intake baseline P-cortisol the bodys response to ACTH measured by cortisol levels after the test and bone density in patients with chronic sinusitis CRS with and without asthma in an unselected population at the Respiratory Clinic cross-sectional In addition at the 4-month follow-up exploratory follow-up pilot project it will be investigated whether good adherence 80 to inhalation therapy nasal steroid and lung steroid and additional treatment with biologicals has a negative effect on the bodys own production of P-cortisol
The purpose of the study is therefore to compare steroid intake baseline P-cortisol the bodys response to ACTH measured by cortisol levels after the test and bone density in patients with chronic sinusitis CRS with and without asthma in an unselected population at the Respiratory Clinic cross-sectional In addition at the 4-month follow-up exploratory follow-up pilot project it will be investigated whether good adherence 80 to inhalation therapy nasal steroid and lung steroid and additional treatment with biologicals has a negative effect on the bodys own production of P-cortisol
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None