Ignite Creation Date:
2024-05-06 @ 6:57 PM
Last Modification Date:
2024-10-26 @ 2:58 PM
Study NCT ID:
NCT05848050
Status:
RECRUITING
Last Update Posted:
2023-07-03
First Post:
2023-04-25
Brief Title:
Evaluation of the Humoral and Tumoral Molecular Alteration Profile of Brain Metastases
Sponsor:
GCS Ramsay Santé pour lEnseignement et la Recherche
Organization:
GCS Ramsay Santé pour lEnseignement et la Recherche
Study Overview
Official Title:
Evaluation of the Humoral and Tumoral Molecular Alteration Profile of Brain Metastases
Status:
RECRUITING
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
METALIQ
Brief Summary:
The purpose of the study is to determine in brain metastases and according to feasibility in liquid biopsies
Molecular alterations including in particular mutations amplifications Copy number gene variants and fusion transcripts identified by high-throughput sequencing
The rate of variation either in gain or in loss of expression of the different messenger Ribonucleic Acids by analysis of the transcriptome
Epigenetic alterations by methylation of deoxyribonucleic acid clusters by methylome chips
Molecular alterations including in particular mutations amplifications Copy number gene variants and fusion transcripts identified by high-throughput sequencing
The rate of variation either in gain or in loss of expression of the different messenger Ribonucleic Acids by analysis of the transcriptome
Epigenetic alterations by methylation of deoxyribonucleic acid clusters by methylome chips
Detailed Description:
This is a single-center prospective interventional exploratory study aimed at comparing the molecular alteration profile of liquid biopsies blood and lumbar puncture to that of brain metastases
The population eligible for the study will consist of any patient with cerebral metastases from a solid cancer at least one of which is accessible to surgical excision
The study consists of comparing between brain metastases and liquid biopsies blood and lumbar puncture the profiles of genomic post-genomic and epigenetic alterations as well as the mutational load To do this the study only requires a lumbar puncture and a blood test
The population eligible for the study will consist of any patient with cerebral metastases from a solid cancer at least one of which is accessible to surgical excision
The study consists of comparing between brain metastases and liquid biopsies blood and lumbar puncture the profiles of genomic post-genomic and epigenetic alterations as well as the mutational load To do this the study only requires a lumbar puncture and a blood test
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None