Ignite Creation Date:
2024-05-06 @ 6:56 PM
Last Modification Date:
2024-10-26 @ 2:57 PM
Study NCT ID:
NCT05841173
Status:
RECRUITING
Last Update Posted:
2023-05-06
First Post:
2023-04-10
Brief Title:
Effects of Weight Loss Management on Cognitive Function in Elderly Women With Obesity
Sponsor:
Federal State Budgetary Scientific Institution Federal Research Centre of Nutrition Biotechnology
Organization:
Federal State Budgetary Scientific Institution Federal Research Centre of Nutrition Biotechnology
Study Overview
Official Title:
Effects of Weight Loss Management on Cognitive Function in Elderly Obese Women
Status:
RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
According to studies the risk of cerebrovascular disease and cognitive decline are associated with age-related changes In addition there is data suggesting a relationship between the progression of this pathology and the presence of obesity and associated metabolic disorders According to to some research weight loss associated with cognitive function decline In this regard the development of effective applicable in real clinical practice methods of non-drug treatment and prevention of cerebrovascular disorders and age-related cognitive decline in people with obesity and metabolic disorders who are at high risk seems to be extremely relevant
The main goal of the study is to compare the effectiveness of various weight loss approaches and to study their effects on the cognitive functions of elderly obesity women
The main goal of the study is to compare the effectiveness of various weight loss approaches and to study their effects on the cognitive functions of elderly obesity women
Detailed Description:
The high prevalence of comorbid pathology characterised the elderly and senile population Particularly comorbid condition is often based on obesity Also an important characteristic of the elderly and senile age is the development of age-related cognitive deficit and progressive decline in cognitive functions that is detected in 608 of people over 65 years old in Russia according to the EVKALIPT study
The prevalence of obesity in the Russian population reaches 40 among the elderly population According to studies the presence of obesity is paradoxically associated with less progression of cognitive function loss and the risk reduction in some populations reaches 40 However the sarcopenic obesity is an independent predictor of cognitive impairment in the elderly Consequently the therapy of obesity in elderly and senile population faces two important aspects the risk of muscle loss and the development of sarcopenia and progressive cognitive decline The described features of this age group are consistent with the well-known obesity paradox in which overweight and obesity are associated with longer life expectancy
The risk of muscle mass reduction and cognitive functions decrease determines the formation of a specialised approach to obesity management in older population Thus the setting of softer and longer-term goals with a gradual decrease in body weight is typical Studies have considered the use of various interventions so far the combination of diet with exercise has proven effectiveness in muscle mass protection At the same time regular exercises reliably protect from cognitive decline Thereby the combination of diet and physical activity is considered as a suitable approach to obesity management in the elderly
Recently there have also been a number of studies evaluating the effectiveness of the ketogenic diet This diet pattern is reliably effective in body weight reduction skeletal muscle mass maintenance and adipose tissue metabolism improvement in the elderly Also the neuroprotective effects of the ketogenic diet have been confirmed by meta-analyses and have made it possible to include it in current guidelines for the prevention and treatment of cognitive impairment However the high frequency of negative effects and the associated low adherence limit the possibilities of using this diet which led to the development of exogenous ketones that allow reaching the levels of blood ketone bodies associated with neuroprotective properties 02-05 mmoll with better portability
The main goal of the study is to compare the effectiveness of various weight loss approaches and to study their effects on the cognitive functions of elderly obesity women
The prevalence of obesity in the Russian population reaches 40 among the elderly population According to studies the presence of obesity is paradoxically associated with less progression of cognitive function loss and the risk reduction in some populations reaches 40 However the sarcopenic obesity is an independent predictor of cognitive impairment in the elderly Consequently the therapy of obesity in elderly and senile population faces two important aspects the risk of muscle loss and the development of sarcopenia and progressive cognitive decline The described features of this age group are consistent with the well-known obesity paradox in which overweight and obesity are associated with longer life expectancy
The risk of muscle mass reduction and cognitive functions decrease determines the formation of a specialised approach to obesity management in older population Thus the setting of softer and longer-term goals with a gradual decrease in body weight is typical Studies have considered the use of various interventions so far the combination of diet with exercise has proven effectiveness in muscle mass protection At the same time regular exercises reliably protect from cognitive decline Thereby the combination of diet and physical activity is considered as a suitable approach to obesity management in the elderly
Recently there have also been a number of studies evaluating the effectiveness of the ketogenic diet This diet pattern is reliably effective in body weight reduction skeletal muscle mass maintenance and adipose tissue metabolism improvement in the elderly Also the neuroprotective effects of the ketogenic diet have been confirmed by meta-analyses and have made it possible to include it in current guidelines for the prevention and treatment of cognitive impairment However the high frequency of negative effects and the associated low adherence limit the possibilities of using this diet which led to the development of exogenous ketones that allow reaching the levels of blood ketone bodies associated with neuroprotective properties 02-05 mmoll with better portability
The main goal of the study is to compare the effectiveness of various weight loss approaches and to study their effects on the cognitive functions of elderly obesity women
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None