Ignite Creation Date:
2024-05-06 @ 6:56 PM
Last Modification Date:
2024-10-26 @ 2:57 PM
Study NCT ID:
NCT05842564
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-05-06
First Post:
2023-04-24
Brief Title:
Autophagy in Paediatric Crohns Disease
Sponsor:
Hospices Civils de Lyon
Organization:
Hospices Civils de Lyon
Study Overview
Official Title:
Autophagic Activity Characterization in Pediatric Crohns Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
P-IBDphagy
Brief Summary:
Crohns disease is a multifactorial complex disease resulting in a between microbiota and immune system Indeed GWAS Genome-Wide Association Studies association study pinpointed polymorphisms as genes susceptibility on more than 200 loci Among them genes coding for proteins involved in autophagy machinery ie ATG16L1 IRGM et NDP52 Autophagy is a ubiquitous intracellular mechanism mandatory for protein and microorganism recycling
So far the role of autophagy in gut inflammation and intestinal homeostasis in Crohns disease patients is partially understand Then investigators plan to evaluate on native cells the autophagic flux in pediatric patients suffering of a Crohns disease compare to controls
So far the role of autophagy in gut inflammation and intestinal homeostasis in Crohns disease patients is partially understand Then investigators plan to evaluate on native cells the autophagic flux in pediatric patients suffering of a Crohns disease compare to controls
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None