Ignite Creation Date:
2024-05-06 @ 6:55 PM
Last Modification Date:
2024-10-26 @ 2:56 PM
Study NCT ID:
NCT05825118
Status:
RECRUITING
Last Update Posted:
2023-04-24
First Post:
2023-03-27
Brief Title:
NL Ratio Versus LA Ratio as a Predictor of Morbidity and Mortality in Sepsis and Septic Shock
Sponsor:
Tanta University
Organization:
Tanta University
Study Overview
Official Title:
Neutrophil-lymphocyte Ratio Versus Lactate-albumin Ratio as a Predictor of Morbidity and Mortality in Patients With Sepsis and Septic Shock
Status:
RECRUITING
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the study is to compare between neutrophil lymphocyte ratio and lactate albumin ratio as a predictor of morbidity and mortality in sepsis and septic shock patients
Detailed Description:
Sepsis is a systemic inflammatory response syndrome caused by infection can lead to life threatening multi-organ dysfunction
Septic shock causes circulatory and metabolic abnormalities leading to increased mortality in hospitalized patients especially in intensive care unit ICU patients
Sepsis can affect the function and number of immune cells including neutrophils lymphocytes and monocytes
Neutrophils play crucial roles in the innate cellular immune system Early higher neutrophil counts correlated with increased sepsis severity
In sepsis lymphocytes decrease owing to the apoptosis mediated by innate response
Reversily number of neutrophils dramatically increase reflecting degree of inflammation
The neutrophil-to-lymphocyte ratio NLR is a novel inflammatory biomarker that can be obtained through blood routine tests it is cost- effective and widely available and it is beneficial to the early recognition of poor prognosis in septic patients
Albumin is a molecule that is the most abundant protein in plasma For a variety of physiological mechanisms albumin has a variety of function including serving as a major buffer extracellular antioxidant immune modulator antidote and transporter in plasma
Increased capillary leakage of albumin is one of the features of SIRS This means that lower albumin levels correlate with severe systemic inflammation and organ failure
Hypoxia and tissue hypo perfusion seen in sepsis play a key role on the development of multi-organ failure in septic patients
Lactic acidosis is one of the best indicators of the insufficient perfusion or development of anaerobic metabolism during septic shock
The inability of liver to metabolize lactate as a result of the deterioration of liver perfusion also increases lactate levels
The measurement of blood lactate levels used to determine tissue hypoxia is rapid inexpensive and easy
Because lactate and albumin levels progress differently as the development of sepsis proceeds a ratio between the two rather than analyzing lactate and albumin alone may be a new and perhaps better indicator for the patients prognosis
Septic shock causes circulatory and metabolic abnormalities leading to increased mortality in hospitalized patients especially in intensive care unit ICU patients
Sepsis can affect the function and number of immune cells including neutrophils lymphocytes and monocytes
Neutrophils play crucial roles in the innate cellular immune system Early higher neutrophil counts correlated with increased sepsis severity
In sepsis lymphocytes decrease owing to the apoptosis mediated by innate response
Reversily number of neutrophils dramatically increase reflecting degree of inflammation
The neutrophil-to-lymphocyte ratio NLR is a novel inflammatory biomarker that can be obtained through blood routine tests it is cost- effective and widely available and it is beneficial to the early recognition of poor prognosis in septic patients
Albumin is a molecule that is the most abundant protein in plasma For a variety of physiological mechanisms albumin has a variety of function including serving as a major buffer extracellular antioxidant immune modulator antidote and transporter in plasma
Increased capillary leakage of albumin is one of the features of SIRS This means that lower albumin levels correlate with severe systemic inflammation and organ failure
Hypoxia and tissue hypo perfusion seen in sepsis play a key role on the development of multi-organ failure in septic patients
Lactic acidosis is one of the best indicators of the insufficient perfusion or development of anaerobic metabolism during septic shock
The inability of liver to metabolize lactate as a result of the deterioration of liver perfusion also increases lactate levels
The measurement of blood lactate levels used to determine tissue hypoxia is rapid inexpensive and easy
Because lactate and albumin levels progress differently as the development of sepsis proceeds a ratio between the two rather than analyzing lactate and albumin alone may be a new and perhaps better indicator for the patients prognosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None