Ignite Creation Date:
2024-05-06 @ 6:54 PM
Last Modification Date:
2024-10-26 @ 2:57 PM
Study NCT ID:
NCT05827562
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-04-25
First Post:
2023-03-30
Brief Title:
Alterations in CD8αβ and CD8αα T Cell Levels in Patients With Rheumatoid Arthritis
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Alterations in CD8αβ and CD8αα T Cell Levels in Patients With Rheumatoid Arthritis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the changes in the frequencies of circulating CD4 and CD4- T cells expressing CD8αα and CD8αβ in peripheral blood of RA patients in comparison with healthy controls Also to correlate circulating and synovial fluid levels of these cells with disease activity score DAS28 and other indices of disease severity
Detailed Description:
Rheumatoid arthritis RA is a chronic inflammatory systemic autoimmune disease of the joints CD4 T cells are predominant in the synovial tissue with increased number of CD8 effector and memory T cells in synovial fluid and tissue of RA patients CD8 functions as a dimer including homodimer CD8αα and heterodimer CD8αβ CD8αβ is a superior T-cell co-receptor that enhances functional avidity CD8αα functions as a TCR corepressor to negatively regulate T cell activation CD8αα T cells are found in human intestine and peripheral blood CD8αα T cells increased markedly in the lesions of psoriasis where they played a pro-inflammatory role The lower percentage of CD8αα mucosa associated-invariant T MAIT cells was found to be associated with MAIT cell dysfunction in gut immunity in necrotizing enterocolitis patients T cells express the CD8β chain either at a high CD8βhigh or low density CD8βlow There was a relative increase in CD8βlow cells in patients with SLE which were associated with an increased disease activity Double positive DP T lymphocytes include CD4CD8αβhigh and CD4CD8αα T cell subsets in the human blood DP8α cells decreased in the blood and colonic mucosa of patients with inflammatory bowel disease compared with healthy individuals CD4CD8αβhigh T cells are present at higher frequencies in some auto-immune diseases Whether CD8αα or CD8αβ T cells contribute to the pathogenesis of RA has not been clarified so far investigators hypothesize that an alteration in the frequency and distribution of these T cell subsets in RA patients might be associated with disease activity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None