Ignite Creation Date:
2024-05-05 @ 6:44 PM
Last Modification Date:
2024-10-26 @ 9:36 AM
Study NCT ID:
NCT00538967
Status:
COMPLETED
Last Update Posted:
2007-10-03
First Post:
2007-10-02
Brief Title:
The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
Sponsor:
Leiden University Medical Center
Organization:
Leiden University Medical Center
Study Overview
Official Title:
The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
Status:
COMPLETED
Status Verified Date:
2007-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The matrix metalloproteinase-9 MMP-9 is considered to play a central role in abdominal aortic aneurysm AAA initiation Doxycycline has direct MMP-9 inhibiting properties in vitro and it effectively suppresses AAA development in rodents Observed inhibition of AAA progression and contradictory findings in human studies evaluating the effect of doxycycline therapy on aortic wall MMP-9 suggest that the effects of doxycycline extend beyond MMP-9 inhibition and that the effect may be dose dependent
Detailed Description:
In this clinical trial we evaluated the effect of two weeks of low 50 mgday medium 100 mgday or high dose 300 mgday doxycycline versus no medication in patients undergoing elective AAA repair The effect of doxycycline treatment on MMP and cysteine proteases and their respective inhibitors was evaluated in an integrative approach
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None