Ignite Creation Date:
2024-05-06 @ 6:54 PM
Last Modification Date:
2024-10-26 @ 2:56 PM
Study NCT ID:
NCT05823662
Status:
COMPLETED
Last Update Posted:
2023-04-24
First Post:
2023-03-16
Brief Title:
Double J Stenting and Sildosin After URSL for Lower Ureteric Stones
Sponsor:
Benha University
Organization:
Benha University
Study Overview
Official Title:
Comparative Study Between DJ Stenting and Sildosin After Uretroscopic Lithotripsy for Lower Ureteric Stones
Status:
COMPLETED
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DJ
Brief Summary:
The aim of this prospective comparative clinical study to compare DJ stenting and Sildosin after ureteroscopic lithotripsy for lower ureteric stones
Detailed Description:
Ureteric calculi are known to affect approximately 10 - 15 of the overall population The incidence of urolithiasis is rising over time Most of these stones are known to pass spontaneously with or without expulsive medical therapy The expulsion of calculus depends on the following factors the calculus size and the location in the ureter Alelign and Petros 2018 The calculi expulsion rates change depending on these factors with the expulsion rate ranging from 40 to 98 for calculi less than 5 mm The calculi which measure 6 mm or more have a spontaneous expulsion rate ranging between 35 to 50
Semirigid ureteroscopy URS lithotripsy has been shown to have high success rates for treating distal ureteric stones in many studies However URS is associated with some drawbacks which may be risky and sometimes problematic
The use of Double J DJ stent after ureteroscopy helps in the passage of residual fragments and prevents pain caused due to mucosal edema and obstruction However many patients complain of stent-related discomfort in the postoperative period There is an additional need for stent removal which is another surgical procedure adding to the cost of treatment Despite its usefulness the morbidity associated with these stents has been considered a potential health problem However many patients complain of stent-related discomfort in the postoperative period There is an additional need for stent removal which is another surgical procedure adding to the cost of treatment
Silodosin is a highly selective alpha-1 adrenergic receptor antagonist which is used in the treatment of lower urinary tract symptoms LUTS Alpha-1 adrenergic receptors are densely found in the smooth muscle cells of the lower urinary tract and silodosin relaxes them and improves the stent-related symptoms SRS and various studies have also shown similar effects It has documented its use in the therapy of ureteric calculus
Semirigid ureteroscopy URS lithotripsy has been shown to have high success rates for treating distal ureteric stones in many studies However URS is associated with some drawbacks which may be risky and sometimes problematic
The use of Double J DJ stent after ureteroscopy helps in the passage of residual fragments and prevents pain caused due to mucosal edema and obstruction However many patients complain of stent-related discomfort in the postoperative period There is an additional need for stent removal which is another surgical procedure adding to the cost of treatment Despite its usefulness the morbidity associated with these stents has been considered a potential health problem However many patients complain of stent-related discomfort in the postoperative period There is an additional need for stent removal which is another surgical procedure adding to the cost of treatment
Silodosin is a highly selective alpha-1 adrenergic receptor antagonist which is used in the treatment of lower urinary tract symptoms LUTS Alpha-1 adrenergic receptors are densely found in the smooth muscle cells of the lower urinary tract and silodosin relaxes them and improves the stent-related symptoms SRS and various studies have also shown similar effects It has documented its use in the therapy of ureteric calculus
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None