Ignite Creation Date:
2024-05-06 @ 6:54 PM
Last Modification Date:
2024-10-26 @ 2:57 PM
Study NCT ID:
NCT05829148
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-04-25
First Post:
2023-04-08
Brief Title:
The Effect of Dexmedetomidine Melatonin and Pregabalin
Sponsor:
Egymedicalpedia
Organization:
Egymedicalpedia
Study Overview
Official Title:
Comparison Between the Effect of Dexmedetomidine Melatonin and Pregabalin on Hypotensive Anesthesia in Patients Undergoing Functional Endoscopic Sinus Surgery
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Various drugs have been used for the purpose nitroglycerine sodium nitroprusside propofol beta blockers calcium channel blockers higher concentrations of inhalational anesthetics etc Since all these drugs have certain limitations there was a search for more safe and effective drug
Detailed Description:
Functional Endoscopic Sinus Surgery FESS is done via endoscope and the area is highly vascular thus it becomes important to minimize bleeding hence we require hypotensive anesthesia
Dexmedetomidine a highly selective α2-receptor agonist that has sedative analgesic anxiolytic and opioid sparing effects without significant respiratory depression it also reduces the need for inhaled anesthetics dexmedetomidine also minimizes postoperative opioid consumption as well as nausea vomiting and anxiety
Melatonin is a neurohormone mainly secreted from the pineal gland by the suprachiasmatic nucleus It possesses a circadian secretion pattern and regulates the biological clock it also offers antiemetic analgesic and anxiolytic effects Due to its effect on both acute and chronic pain melatonin available in 5mg tablet form fulfills a beneficial role in reducing postoperative opioid consumption while minimizing nausea and vomiting
Pregabalin whose structure is similar to the inhibitory neurotransmitter gamma-aminobutyric acid GABA possesses analgesic and anxiolytic activities and is effective in alleviating the neuropathic component of acute nociceptive pain of surgery It has also been used as premedication to attenuate the hemodynamic stress response to laryngoscopy and intubation and to decrease intraoperative anesthetic requirement
Dexmedetomidine a highly selective α2-receptor agonist that has sedative analgesic anxiolytic and opioid sparing effects without significant respiratory depression it also reduces the need for inhaled anesthetics dexmedetomidine also minimizes postoperative opioid consumption as well as nausea vomiting and anxiety
Melatonin is a neurohormone mainly secreted from the pineal gland by the suprachiasmatic nucleus It possesses a circadian secretion pattern and regulates the biological clock it also offers antiemetic analgesic and anxiolytic effects Due to its effect on both acute and chronic pain melatonin available in 5mg tablet form fulfills a beneficial role in reducing postoperative opioid consumption while minimizing nausea and vomiting
Pregabalin whose structure is similar to the inhibitory neurotransmitter gamma-aminobutyric acid GABA possesses analgesic and anxiolytic activities and is effective in alleviating the neuropathic component of acute nociceptive pain of surgery It has also been used as premedication to attenuate the hemodynamic stress response to laryngoscopy and intubation and to decrease intraoperative anesthetic requirement
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None