Ignite Creation Date:
2024-05-06 @ 6:53 PM
Last Modification Date:
2024-10-26 @ 2:56 PM
Study NCT ID:
NCT05817188
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-04-26
First Post:
2023-04-04
Brief Title:
Medication Repurposing to Stop Cognitive Decline in Dementia
Sponsor:
Karolinska Institutet
Organization:
Karolinska Institutet
Study Overview
Official Title:
Translational Identification of Medication Repurposing Candidates to Slow Cognitive Decline in Dementia
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Dementia creates a great personal and societal burden and there are currently no treatments to stop memory loss Many patients with dementia take medications to treat other conditions eg high blood pressure and cholesterol Some of these medications may have central effects on the pathophysiological processes leading to dementia
Medication repurposing is a cost and time-effective way to discover new treatments Swedish registers are a unique tool to detect medication candidates for repurposing The Swedish Dementia Registry SveDem has 100000 patients and ca 144000 measures of cognition over time measured with the Mini-Mental State Examination-MMSE making it perfect to examine whether certain medications are associated with less cognitive decline in patients with dementia Cholesterol and kidney function affect treatment and cognition and are available for 25000 patients The investigators propose a study combining traditional cohort studies and newer artificial intelligence machine learning techniques to detect medications associated with slower cognitive decline in patients from SveDem The investigators will test pre-specified hypotheses since the investigators suspect specific medications are better candidates to prevent cognitive decline but the investigators will also let the machine learning algorithms explore the data to find associations that the investigators do not suspect in advance Finally the candidate medications will be tested in animal and cellular models to determine the mechanisms of their effects
Medication repurposing is a cost and time-effective way to discover new treatments Swedish registers are a unique tool to detect medication candidates for repurposing The Swedish Dementia Registry SveDem has 100000 patients and ca 144000 measures of cognition over time measured with the Mini-Mental State Examination-MMSE making it perfect to examine whether certain medications are associated with less cognitive decline in patients with dementia Cholesterol and kidney function affect treatment and cognition and are available for 25000 patients The investigators propose a study combining traditional cohort studies and newer artificial intelligence machine learning techniques to detect medications associated with slower cognitive decline in patients from SveDem The investigators will test pre-specified hypotheses since the investigators suspect specific medications are better candidates to prevent cognitive decline but the investigators will also let the machine learning algorithms explore the data to find associations that the investigators do not suspect in advance Finally the candidate medications will be tested in animal and cellular models to determine the mechanisms of their effects
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None