Ignite Creation Date:
2024-05-06 @ 6:51 PM
Last Modification Date:
2024-10-26 @ 2:55 PM
Study NCT ID:
NCT05806619
Status:
COMPLETED
Last Update Posted:
2023-04-10
First Post:
2023-03-28
Brief Title:
Glioma Biomolecular Aspects
Sponsor:
Regina Elena Cancer Institute
Organization:
Regina Elena Cancer Institute
Study Overview
Official Title:
Glioma BIOMOLECULAR Aspects From Tissue to Radiomics
Status:
COMPLETED
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GLIOMA
Brief Summary:
Main limitations in Glioma studies are due to the wide heterogeneity and genetic instability of the tumor and to the fact that the molecular informations are static ie obtained on the tumor at its onset Instead spontaneous or therapy-induced variations are difficult to evaluate and they would need further sampling of the tumor throughout the clinical history Currently these data are more and more routinely used not only for diagnostics but also in the clinical management of the patient
Furthermore microenvironment study is becoming increasingly important It is also important correlate morpho-functional pathway and brain Magnetic Resonance
Therefore the main goal of the study is to correlate the data obtained with morphological site signal intensity margins behavior after contrast medium infusion mismatch between T2 and FLAIR sequences and non-morphological MR imaging through a radiomic approach and Diffusion and Perfusion study with molecular data relating to the IDH mutation MGMT gene promoter methylation 1p19q co-deletion and EGFRvIII expression
Furthermore it is proposed to carry out a correlation between the radiological data and the mutations found in the NGS panel
Furthermore microenvironment study is becoming increasingly important It is also important correlate morpho-functional pathway and brain Magnetic Resonance
Therefore the main goal of the study is to correlate the data obtained with morphological site signal intensity margins behavior after contrast medium infusion mismatch between T2 and FLAIR sequences and non-morphological MR imaging through a radiomic approach and Diffusion and Perfusion study with molecular data relating to the IDH mutation MGMT gene promoter methylation 1p19q co-deletion and EGFRvIII expression
Furthermore it is proposed to carry out a correlation between the radiological data and the mutations found in the NGS panel
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None