Ignite Creation Date:
2024-05-06 @ 6:51 PM
Last Modification Date:
2024-10-26 @ 2:55 PM
Study NCT ID:
NCT05801718
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-04-06
First Post:
2023-03-26
Brief Title:
Growth Parameters Body Mass Index in Children With Chronic Diseases
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Growth Parameters Body Mass Index in Children With Chronic Diseases
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Deviations from the normal pattern of growth may be the first clues to pathology as in many chronic diseases evaluated clinically by anthropometric measurements body mass index Growth impairment in children with chronic diseases is associated with disruption of the growth hormone GH and predominantly results from undernutrition chronic inflammation and prolonged corticosteroid treatment
Undernutrition leads to major adaptations in the endocrine system towards conserving energy diverting substrates away from growth and reproduction and providing alternative sources of energy for critical body homeostasis chronic inflammatory processes exacerbate undernutrition through proinflammatory cytokines such as interleukin-16 and tumor necrosis factor These growth-regulating mechanisms are disturbed further by corticosteroids used in some chronic conditions for their anti-inflammatory and immunosuppressive properties
Growth impairment occurs with many chronic conditions e g Congenital heart dieases CHD chronic pulmonary diseases such as bronchial asthma Gastrointestinal diseases sch as inflammatory bowel disease Chronic liver diseases Chronic renal diseases Chronic hemolytic anemia and chronic Central nervous system diseases
Undernutrition leads to major adaptations in the endocrine system towards conserving energy diverting substrates away from growth and reproduction and providing alternative sources of energy for critical body homeostasis chronic inflammatory processes exacerbate undernutrition through proinflammatory cytokines such as interleukin-16 and tumor necrosis factor These growth-regulating mechanisms are disturbed further by corticosteroids used in some chronic conditions for their anti-inflammatory and immunosuppressive properties
Growth impairment occurs with many chronic conditions e g Congenital heart dieases CHD chronic pulmonary diseases such as bronchial asthma Gastrointestinal diseases sch as inflammatory bowel disease Chronic liver diseases Chronic renal diseases Chronic hemolytic anemia and chronic Central nervous system diseases
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None