Ignite Creation Date:
2024-05-06 @ 6:50 PM
Last Modification Date:
2024-10-26 @ 2:56 PM
Study NCT ID:
NCT05807581
Status:
RECRUITING
Last Update Posted:
2024-03-13
First Post:
2023-03-13
Brief Title:
Clinical Molecular and Electrophysiological Profiling of Parkinsons Disease the Role of Non-pharmacological Therapies
Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Organization:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study Overview
Official Title:
Clinical Molecular and Electrophysiological Profiling of Parkinsons Disease the Role of Non-pharmacological Therapies
Status:
RECRUITING
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In Parkinsons disease PD direct evidence linking inflammation to the harmful activities of alpha-synuclein a-syn aggregates the disease onset and its progression is still lacking This translational project aims to reveal the causal relationship between a-syn and inflammation The investigators will also investigate the mechanisms underlying the beneficial effects of two non-pharmacological approaches motor exercise and neuromodulation with particular focus on neuroinflammation and brain-derived neurotrophic factor BDNF production the investigators will investigate the molecular pathways and synaptic alterations underlying disease progression This will be paralleled by a clinical study in which clinical assessment will be associated with cerebrospinal fluid CSF and blood neurodegeneration and inflammatory biomarkers measures Then the investigators will test the hypothesis that intensive exercise and neuromodulation may reduce neuroinflammation and a-syn spreading via the activation of BDNF-related pathways
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None