Ignite Creation Date:
2024-05-06 @ 6:50 PM
Last Modification Date:
2024-10-26 @ 2:55 PM
Study NCT ID:
NCT05800028
Status:
RECRUITING
Last Update Posted:
2023-04-27
First Post:
2023-03-23
Brief Title:
Memory and Social Interactions
Sponsor:
University Hospital Caen
Organization:
University Hospital Caen
Study Overview
Official Title:
Memory and Social Interactions Study in Alzheimers Disease and Semantic Progressive Aphasia
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MEMSO
Brief Summary:
Memory and social interaction are intimately linked On the one hand social interaction is a privileged context for learning and on the other hand appropriate social interactions involve remembering the partners encountered and previous exchanges People with Alzheimers disease classic syndrome variant AD have a major impairment of episodic memory while people with the semantic variant of primary progressive aphasia SPPA are characterized by semantic disorders in the foreground associated with changes in their social behavior with a tendency to egocentricity In both cases patients frequently have reduced social interactions Although social interaction situations seem to constitute a privileged learning context their effectiveness for patients with cognitive disorders must be evaluated and the conditions under which they are effective must be established The main objective of this study is to determine whether social interaction constitutes a beneficial context for learning new information and whether the presence of social behavior disorders alters this benefit More broadly the goal is to better understand the mechanisms underlying the possible beneficial effect of learning in social contexts and to clarify the links between memory performance in different social contexts cognitive disorders social behavioral changes and personality traits Finally a description will be made of the brain substrates associated with memory performance obtained during learning in social contexts in order to investigate their particularities Thirty couples each including a person with AD 16 couples each including a person with SPPA and 46 couples of persons without cognitive complaints HC one of which will be matched in gender and age to one of the patients will be included in the study Participants will perform image location learning in a grid in three social contexts in which both members of the couple are involved 1 simple presence of others 2 by observation and 3 in collaboration A psychometric assessment including social cognition and classical tests assessing memory and questionnaires concerning global executive functioning social behavior and personality will be offered to all participants Patients in the AD and SPPA groups and the matched individual in the HC group will undergo anatomical and functional brain magnetic resonance imaging MRI
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None