Ignite Creation Date:
2024-05-06 @ 6:49 PM
Last Modification Date:
2024-10-26 @ 2:55 PM
Study NCT ID:
NCT05793125
Status:
COMPLETED
Last Update Posted:
2023-04-04
First Post:
2023-03-19
Brief Title:
Pulmonary Artery Doppler And Neonatal Outcome In Hypertensive Disorders Of Pregnancy
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Correlation Between Pulmonary Artery Doppler And Neonatal Outcome In Hypertensive Disorders Of Pregnancy
Status:
COMPLETED
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To correlate fetal Pulmonary artery Doppler parameters with neonatal outcome in patients diagnosed with hypertensive disorders of pregnancy
Detailed Description:
Hypertensive disorders include gestational hypertension preeclampsia chronic hypertension preeclampsia superimposed on chronic hypertension They complicate up to 10 of pregnancies As a group they are one member of the deadly triad along with hemorrhage and infection that contributes greatly to maternal morbidity
Preeclampsia either alone or superimposed on chronic hypertension is the most dangerous Most hypertension related deaths are preventable Also nonsevere preeclampsia may progress rapidly to severe disease causing headache or visual disturbance that precede eclampsia They also cause epigastic or right upper quadrant pain and elevated hepatic transaminases that frequently accompany hepatocellular necrosis ischemia and edema thrombocytopenia that represents platelet activation and aggregation microangiopathic hemolysis renal involvement and placental abruption On the long term preeclampsia is also associated with adverse health problems including chronic hypertension ischemic heart disease atherosclerosis cardiomyopathy peripheral vascular disease type 2 diabetes dyslipidemia obesity and metabolic syndrome
Termination of pregnancy is the only known cure for preeclampsia Moreover expectant management of preterm severe preeclampsia leads to disastrous results as increase in perinatal mortality rate placental abruption eclampsia renal failure hypertensive encephalopathy intracranial hemorrhage or even rupture in hepatic hematoma
Early attempts have been made to predict fetal maturity on the basis antenatal ultrasonographic parameters including lung characteristics bowel pattern placental grading the presence or absence of intraamniotic particles vernix caseosa and the epiphyseal ossification centers appearance and enlargement
More recently fetal pulmonary artery Doppler has been used to predict neonatal respiratory rate RDS It was found that an elevated acceleration-to-ejection time ratio was significantly associated with neonatal RDS However such indices cannot be generalized in all cases especially those with hypertensive disorders of pregnancy who have abnormal trophoblastic invasion of uterine vessels affecting fetoplacental circulation resistance
To the best of our knowledge no available studies have correlated fetal pulmonary artery Doppler indices with neonatal outcomes in patients with hypertensive disorders of pregnancy Presence of such signs of maturity can aid the obstetrician to choose the most appropriate timing for termination especially in low income countries who have limited access to neonatal intensive care units Being cost effective and non invasive ultrasonography is used as a routine obstetrics scanning tool This study will help determine the utility of ultrasound and Doppler in assessing the fetal lung maturity in such patients
Preeclampsia either alone or superimposed on chronic hypertension is the most dangerous Most hypertension related deaths are preventable Also nonsevere preeclampsia may progress rapidly to severe disease causing headache or visual disturbance that precede eclampsia They also cause epigastic or right upper quadrant pain and elevated hepatic transaminases that frequently accompany hepatocellular necrosis ischemia and edema thrombocytopenia that represents platelet activation and aggregation microangiopathic hemolysis renal involvement and placental abruption On the long term preeclampsia is also associated with adverse health problems including chronic hypertension ischemic heart disease atherosclerosis cardiomyopathy peripheral vascular disease type 2 diabetes dyslipidemia obesity and metabolic syndrome
Termination of pregnancy is the only known cure for preeclampsia Moreover expectant management of preterm severe preeclampsia leads to disastrous results as increase in perinatal mortality rate placental abruption eclampsia renal failure hypertensive encephalopathy intracranial hemorrhage or even rupture in hepatic hematoma
Early attempts have been made to predict fetal maturity on the basis antenatal ultrasonographic parameters including lung characteristics bowel pattern placental grading the presence or absence of intraamniotic particles vernix caseosa and the epiphyseal ossification centers appearance and enlargement
More recently fetal pulmonary artery Doppler has been used to predict neonatal respiratory rate RDS It was found that an elevated acceleration-to-ejection time ratio was significantly associated with neonatal RDS However such indices cannot be generalized in all cases especially those with hypertensive disorders of pregnancy who have abnormal trophoblastic invasion of uterine vessels affecting fetoplacental circulation resistance
To the best of our knowledge no available studies have correlated fetal pulmonary artery Doppler indices with neonatal outcomes in patients with hypertensive disorders of pregnancy Presence of such signs of maturity can aid the obstetrician to choose the most appropriate timing for termination especially in low income countries who have limited access to neonatal intensive care units Being cost effective and non invasive ultrasonography is used as a routine obstetrics scanning tool This study will help determine the utility of ultrasound and Doppler in assessing the fetal lung maturity in such patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None