Ignite Creation Date:
2024-05-06 @ 6:49 PM
Last Modification Date:
2024-10-26 @ 2:55 PM
Study NCT ID:
NCT05793372
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-05-17
First Post:
2023-03-20
Brief Title:
Hyperhomocysteinemia in Alzheimers Disease
Sponsor:
Central Hospital Nancy France
Organization:
Central Hospital Nancy France
Study Overview
Official Title:
Hyperhomocysteinemia in Alzheimers Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Hcy-MA
Brief Summary:
Alzheimers disease AD is the most common neurodegenerative disease Age is its main risk factor AD is a multifactorial disease combining genetic and environmental risk factors Autosomal dominant mutations have been identified PSEN1 PSEN2 APP leading to earlier and more severe forms of the disease Other genetic risk factors have been identified such as the ε4 allele of the APOE gene The environment also plays a major role with the identification of several risk factors such as air pollution or nutritional deficiencies
AD patients frequently present hyperhomocysteinemia a consequence of a dysfunction of monocarbon metabolism Homocysteine is an amino acid involved in the metabolism of methionine and cysteine High concentrations of homocysteine can be deleterious to the central nervous system
Most prospective studies have shown that elevated homocysteine is a predictor of undefined cognitive impairment or AD Other studies have focused on clinical data and in particular on cognitive function For example a meta-analysis found an inverse correlation between MMSE score and homocysteine level
Thus our study seeks to evaluate the impact of hyperhomocysteinemia on the severity and early onset of AD while knowing the presence or absence of genetic risk factors associated with AD
AD patients frequently present hyperhomocysteinemia a consequence of a dysfunction of monocarbon metabolism Homocysteine is an amino acid involved in the metabolism of methionine and cysteine High concentrations of homocysteine can be deleterious to the central nervous system
Most prospective studies have shown that elevated homocysteine is a predictor of undefined cognitive impairment or AD Other studies have focused on clinical data and in particular on cognitive function For example a meta-analysis found an inverse correlation between MMSE score and homocysteine level
Thus our study seeks to evaluate the impact of hyperhomocysteinemia on the severity and early onset of AD while knowing the presence or absence of genetic risk factors associated with AD
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None