Ignite Creation Date:
2024-05-06 @ 6:49 PM
Last Modification Date:
2024-10-26 @ 2:55 PM
Study NCT ID:
NCT05793424
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-03-31
First Post:
2023-03-20
Brief Title:
Establishment of a CSF Bank for the Development of Biomarkers of Smooth Muscle Cell SMC Damage in Monogenic Cerebral Small Vessel Disease
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Establishment of a CSF Bank for the Development of Biomarkers of Smooth Muscle Cell Damage in Monogenic Cerebral Small Vessel Disease CSF-cSVD-biobank -- Constitution dUne Banque de LCR Pour le développement de Biomarqueurs dAtteinte Des Cellules Musculaires Lisses Dans Les Pathologies Micro-vasculaires cérébrales monogéniques CSF-cSVD-biobank
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CSF-cSVD
Brief Summary:
The main objective of this research is to obtain biological markers of smooth muscle cells dysfunction or degeneration in cerebral small vessel diseases
The aim of this research is therefore to build up a biocollection of CSF and blood samples from 1 patients with CADASIL disease the most common form of cSVD responsible for an accumulation of the NOTCH3 protein in the microvessel wall 2 patients with other forms of monogenic cSVD rarer which are not responsible for an accumulation of this protein despite the damage to the smooth muscle cells of the vessel wall and 3 control patients without cSVD collected in the context of care
This bio-collection will allow the identification and assay of markers testifying to the damage of the smooth muscle cells SMC in different types of cSVD of hereditary origin the first of which will be the soluble NOTCH3 protein
The aim of this research is therefore to build up a biocollection of CSF and blood samples from 1 patients with CADASIL disease the most common form of cSVD responsible for an accumulation of the NOTCH3 protein in the microvessel wall 2 patients with other forms of monogenic cSVD rarer which are not responsible for an accumulation of this protein despite the damage to the smooth muscle cells of the vessel wall and 3 control patients without cSVD collected in the context of care
This bio-collection will allow the identification and assay of markers testifying to the damage of the smooth muscle cells SMC in different types of cSVD of hereditary origin the first of which will be the soluble NOTCH3 protein
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None