Ignite Creation Date:
2024-05-06 @ 6:48 PM
Last Modification Date:
2024-10-26 @ 2:54 PM
Study NCT ID:
NCT05780216
Status:
COMPLETED
Last Update Posted:
2023-09-21
First Post:
2023-02-23
Brief Title:
Mindfulness and Psychedelics
Sponsor:
Milan Scheidegger
Organization:
Psychiatric University Hospital Zurich
Study Overview
Official Title:
Mindfulness and Psychedelics A Combined Neurophenomenological and Pharmacological Approach to the Characterization of Mindfulness States in Experienced Meditators
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators are doing this project to investigate potential neurophysiological synergy effects between mindfulness meditation and psychedelics Previous studies have found that both mindfulness and psychedelics like psilocybin modulate neural activity and connectivity of the same brain network However little is known about the potential interactions between mindfulness meditation and psychedelics The indigenous plant preparation Ayahuasca is particularly interesting for the combination with mindfulness meditation It contains two components NN-dimethyltryptamine DMT and harmine which are very similar to the bodys own messenger substance serotonin and increase its effect in the body The investigators would now like to find out how these corresponding networks change in experienced meditators after DMTHarmine-enhanced mindfulness meditation and how this affects their subjective experience For this functional MRI imaging will be performed as well as psychometric assessments and detailed experiential interviews before and after a three-day meditation retreat Participants will be randomly assigned to one of two groups One group receives DMT and harmine during the sitting meditation on the second day the other group receives a corresponding placebo Neither the participants nor the investigator know who will receive a placebo or the combination of DMTharmine on the day of the experiment The pre- and post-measurements of the MRI imaging and psychometric questionnaires of the DMTHarmine group are compared with those of the placebo control group By examining the synergistic effects of mindfulness meditation and DMTharmine the aim of this study is to contribute to a comprehensive understanding of the neurophenomenology of rare and inaccessible phenomena of consciousness
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None