Ignite Creation Date:
2024-05-06 @ 6:48 PM
Last Modification Date:
2024-10-26 @ 2:55 PM
Study NCT ID:
NCT05789407
Status:
COMPLETED
Last Update Posted:
2023-11-18
First Post:
2023-03-05
Brief Title:
Organic Pollutants in Pelvic Endometriosis
Sponsor:
Jagiellonian University
Organization:
Jagiellonian University
Study Overview
Official Title:
Is Exposure to Persistent Organic Pollutants Linked to Pelvic Endometriosis
Status:
COMPLETED
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The health toxicity of polycyclic aromatic hydrocarbons PAHs present in air and food generated during energy production and waste incineration is well known PAHs can activate the aryl hydrocarbon receptor which may interact with classic estrogen receptors and modify estrogen-dependent inflammation in endometriosis There is no data on the hypothetical role of PAHs in the etiopathogenesis of endometriosis The aim was to compare PAHs concentrations in visceral fat in women with endometriosis and idiopathic infertility
Detailed Description:
A prospective cohort tertiary-center study includes women undergoing laparoscopy due to pelvic endometriosis arm 1 orand idiopathic infertility arm 2 A sample of 1 ml of the greater omentum is collected intraoperatively for detection of 16 PAHs ie acenaphthene acenaphthylene anthracene fluoranthene fluorene naphthalene phenanthrene pyrene benzaanthracene benzobfluoranthene benzokfluoranthene benzoghiperylene benzoapyrene chrysene dibenzahanthracene and indeno123-cdpyrene by gas chromatography-isotope dilution mass spectrometry method The concentration of selected PAHs in visceral fat in both populations will be compared The correlation of concentrations of selected PAHs with the occurrence of infertility pelvic pain syndrome intensity of pain peritoneal adhesions and the degree of endometriosis will be checked
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None