Ignite Creation Date:
2024-05-06 @ 6:46 PM
Last Modification Date:
2024-10-26 @ 2:54 PM
Study NCT ID:
NCT05775484
Status:
RECRUITING
Last Update Posted:
2023-05-11
First Post:
2023-02-10
Brief Title:
Exercise to Slow Cardiovascular Ageing Progression
Sponsor:
National Heart Centre Singapore
Organization:
National Heart Centre Singapore
Study Overview
Official Title:
Exercise to Slow Cardiovascular Ageing Progression
Status:
RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In ageing deleterious alterations in cardiovascular CV structure and function increase risks of ageing-related cardiovascular disease CVD Investigators found that these CV alterations were associated with circulating serum metabolites suggesting a metabolic basis to CV ageing Investigators hypothesize that modification of these metabolites by intervention such as exercise may retard CV alterations and reduce CVD in ageing
Detailed Description:
Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise At the start and end of study participants will undergo cardiovascular imaging and metabolic profiling Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function
Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations
Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None